Literature DB >> 2546903

Nephrotoxicity of pyrroloquinoline quinone in rats.

A Watanabe, N Hobara, T Ohsawa, T Higashi, T Tsuji.   

Abstract

When pyrroloquinoline quinone (PQQ) was intraperitoneally injected into rats daily for 4 days at a dose of 11.5 mg/kg body weight/injection, functional and morphologic changes of the kidneys were clearly observed. The most prominent finding was necrotic and degenerative changes of the proximal tubular epithelium as well as hematuria and an elevation of serum creatinine concentration.

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Year:  1989        PMID: 2546903

Source DB:  PubMed          Journal:  Hiroshima J Med Sci        ISSN: 0018-2052


  2 in total

1.  Protective Effect of Pyrroloquinoline Quinone (PQQ) in Rat Model of Intracerebral Hemorrhage.

Authors:  Hongjian Lu; Jiabing Shen; Xinjian Song; Jianbin Ge; Rixin Cai; Aihua Dai; Zhongli Jiang
Journal:  Cell Mol Neurobiol       Date:  2015-03-29       Impact factor: 5.046

2.  Effects of Diet Supplemented with Excess Pyrroloquinoline Quinone Disodium on Growth Performance, Blood Parameters and Redox Status in Weaned Pigs.

Authors:  Dongxu Ming; Caiyun Huang; Wenhui Wang; Zijie Wang; Chenyu Shi; Xindi Yin; Linlin Sun; Youjun Gao; Fenglai Wang
Journal:  Animals (Basel)       Date:  2021-02-01       Impact factor: 2.752

  2 in total

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