Antibody patterns vary arbitrarily between cerebrospinal fluid and aqueous humor of the individual multiple sclerosis patient: specificity-independent pathological B cell function.

Intrathecal specific antibodies in multiple sclerosis (MS), core of several disease models, are functionally ambiguous. Parallel investigation of cerebrospinal fluid (CSF) and aqueous humor (AH) from 22 MS patients showed similar immune reactions in both compartments but in the individual patient we observed arbitrarily varying differences for specific antibody- (12/14), oligoclonal IgG- (7/8) and isotype patterns. Properties of polyspecific antibodies are consistent with B cells immigrating affinity-maturated, isotype-specific, producing low amounts of antibodies without local target antigen in the brain. A local, arbitrarily varying, specificity-independent, self-organizing B cell activity questions actual disease models for MS and may explain the emerging discontinuity of neuropathology and symptoms in space and time.