| Literature DB >> 25468565 |
Kevin R Mott1, Hadi Maazi2, Sariah J Allen1, Mandana Zandian1, Harry Matundan1, Yasamin N Ghiasi2, Behrooz G Sharifi3, David Underhill4, Omid Akbari2, Homayon Ghiasi5.
Abstract
Recently, we have reported that CD8α(+) DCs, rather than CD8(+) T cells, are involved in the establishment and maintenance of HSV-1 latency in the trigeminal ganglia (TG) of ocularly infected mice. In the current study, we investigated whether similar results can be obtained using Batf3(-/-) mice that previously were reported to lack CD8α(+) DCs. However, our results demonstrate that Batf3(-/-) mice, without any known infection, express CD8α(+) DCs. Consequently, due to the presence of CD8α(+) DCs, no differences were detected in the level of HSV-1 latency between Batf3(-/-) mice compared with wild type control mice.Entities:
Keywords: Compensation; Dendritic cells; HSV-1; Knockout; Latency
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Year: 2014 PMID： 25468565 PMCID： PMC4355210 DOI： 10.1016/j.imbio.2014.10.019
Source DB: PubMed Journal: Immunobiology ISSN： 0171-2985 Impact factor: 3.144