Literature DB >> 2546812

An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues.

P Cohen1, S Klumpp, D L Schelling.   

Abstract

The type 2A protein phosphatases in mammalian tissue extracts are inhibited completely and specifically by 1-2 nM okadaic acid. In contrast, type 1 protein phosphatases are hardly affected at these concentrations, complete inhibition requiring 1 microM okadaic acid. These observations have been exploited to develop an improved procedure for the identification and quantitation of type 1, type 2A and type 2C protein phosphatases in tissue extracts.

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Year:  1989        PMID： 2546812     DOI： 10.1016/0014-5793(89)80803-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  131 in total

1.  Effect of anti-regucalcin antibody on neutral phosphatase activity in rat liver cytosol: involvement of endogenous regucalcin.

Authors:  M Omura; M Yamaguchi
Journal:  Mol Cell Biochem       Date:  1999-07       Impact factor: 3.396

2.  Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.

Authors:  S E Merrick; J Q Trojanowski; V M Lee
Journal:  J Neurosci       Date:  1997-08-01       Impact factor: 6.167

3.  Protein phosphatase 2A is a specific protamine-kinase-inactivating phosphatase.

Authors:  G D Amick; S A Reddy; Z Damuni
Journal:  Biochem J       Date:  1992-11-01       Impact factor: 3.857

4.  Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing.

Authors:  J E Mermoud; P Cohen; A I Lamond
Journal:  Nucleic Acids Res       Date:  1992-10-25       Impact factor: 16.971

5.  Rho kinase signaling pathways during stretch in primary alveolar epithelia.

Authors:  Brian C DiPaolo; Susan S Margulies
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2012-01-27       Impact factor: 5.464

Review 6.  The regulation and function of protein phosphatases in the brain.

Authors:  A T Sim
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

7.  Differential activation of the transcription factor cyclic AMP response element binding protein (CREB) in macrophages following infection with pathogenic and nonpathogenic mycobacteria and role for CREB in tumor necrosis factor alpha production.

Authors:  Shannon K Roach; Seong-Beom Lee; Jeffrey S Schorey
Journal:  Infect Immun       Date:  2005-01       Impact factor: 3.441

8.  Identification of high levels of type 1 and type 2A protein phosphatases in higher plants.

Authors:  C MacKintosh; P Cohen
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

9.  Plant protein phosphatases. Subcellular distribution, detection of protein phosphatase 2C and identification of protein phosphatase 2A as the major quinate dehydrogenase phosphatase.

Authors:  C MacKintosh; J Coggins; P Cohen
Journal:  Biochem J       Date:  1991-02-01       Impact factor: 3.857

10.  TPD1 of Saccharomyces cerevisiae encodes a protein phosphatase 2C-like activity implicated in tRNA splicing and cell separation.

Authors:  M K Robinson; W H van Zyl; E M Phizicky; J R Broach
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272
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