Literature DB >> 2546788

Effect of interleukin-1 on adrenocortical activity in intact and hypothalamic deafferentated male rats.

H Ovadia1, O Abramsky, V Barak, N Conforti, D Saphier, J Weidenfeld.   

Abstract

The present study was designed to elucidate the site of action of interleukin 1 (IL-1) modulation of the hypothalamic-hypophyseal-adrenal (HHA) axis. An intraperitoneal injection of recombinant human IL-1 beta (160 U/rat) significantly elevated serum levels of ACTH and corticosterone (CS). In rats with complete mediobasal hypothalamic deafferentation, the HHA response to IL-1 was inhibited. An intracerebroventricular injection of rIL-1 (2 U/rat) caused a marked increase in serum ACTH and CS. These results suggest that IL-1 activates the HHA axis by a direct effect upon the brain, and that intact neural connections between the mediobasal hypothalamus and extrahypothalamic brain regions are essential for IL-1-induced HHA responses.

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Year:  1989        PMID： 2546788     DOI： 10.1007/BF00253643

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  12 in total

1.  Effects of interleukin-1 on hormone release from normal rat pituitary cells in primary culture.

Authors:  A Uehara; S Gillis; A Arimura
Journal:  Neuroendocrinology       Date:  1987-05       Impact factor: 4.914

2.  Corticotropin-releasing activity of monokines.

Authors:  B M Woloski; E M Smith; W J Meyer; G M Fuller; J E Blalock
Journal:  Science       Date:  1985-11-29       Impact factor: 47.728

3.  Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1.

Authors:  F Berkenbosch; J van Oers; A del Rey; F Tilders; H Besedovsky
Journal:  Science       Date:  1987-10-23       Impact factor: 47.728

4.  Gonadotrophic hormone secretion in female rats after partial or total interruption of neural afferents to the medial basal hypothalamus.

Authors:  B Halász; R A Gorski
Journal:  Endocrinology       Date:  1967-04       Impact factor: 4.736

5.  Corticotrophin and corticosterone secretory patterns following acute neurogenic stress, in intact and in variously hypothalamic deafferented male rats.

Authors:  R Siegel; I Chowers; N Conforti; S Feldman
Journal:  Brain Res       Date:  1980-04-28       Impact factor: 3.252

6.  Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones.

Authors:  H Besedovsky; A del Rey; E Sorkin; C A Dinarello
Journal:  Science       Date:  1986-08-08       Impact factor: 47.728

7.  ACTH and corticosterone secretion following insulin in intact and in variously hypothalamic deafferented male rats.

Authors:  J Weidenfeld; R A Siegel; S Feldman; N Conforti; I Chowers
Journal:  Exp Brain Res       Date:  1982       Impact factor: 1.972

8.  Virus-induced corticosterone in hypophysectomized mice: a possible lymphoid adrenal axis.

Authors:  E M Smith; W J Meyer; J E Blalock
Journal:  Science       Date:  1982-12-24       Impact factor: 47.728

9.  Corticotrophin and corticosterone secretion following delta 1-Tetrahydrocannabinol, in intact and in hypothalamic deafferentated male rats.

Authors:  M Puder; J Weidenfeld; I Chowers; I Nir; N Conforti; R A Siegel
Journal:  Exp Brain Res       Date:  1982       Impact factor: 1.972

10.  Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).

Authors:  I Gery; B H Waksman
Journal:  J Exp Med       Date:  1972-07-01       Impact factor: 14.307
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  1 in total

1.  Hyperprolactinaemia in hypophysectomized or intact male rats and the development of adjuvant arthritis.

Authors:  M Neidhart; E W Flückiger
Journal:  Immunology       Date:  1992-11       Impact factor: 7.397
  1 in total

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