Literature DB >> 25467627

The conserved clag multigene family of malaria parasites: essential roles in host-pathogen interaction.

Ankit Gupta1, Girija Thiruvengadam1, Sanjay A Desai1.   

Abstract

The clag multigene family is strictly conserved in malaria parasites, but absent from neighboring genera of protozoan parasites. Early research pointed to roles in merozoite invasion and infected cell cytoadherence, but more recent studies have implicated channel-mediated uptake of ions and nutrients from host plasma. Here, we review the current understanding of this gene family, which appears to be central to host-parasite interactions and an important therapeutic target. Published by Elsevier Ltd.

Entities:  

Keywords:  antimalarial drug development; clag multigene family; cytoadherence; epigenetics; gene regulation; host-pathogen interactions; malaria parasites; merozoite invasion; nutrient channels

Mesh：

Substances：

Year:  2014        PMID： 25467627      PMCID： PMC4312497          DOI： 10.1016/j.drup.2014.10.004

Source DB:  PubMed          Journal:  Drug Resist Updat        ISSN： 1368-7646            Impact factor:   18.500


  96 in total

1.  Inhibition of Plasmodium falciparum clag9 gene function by antisense RNA.

Authors:  D L Gardiner; D C Holt; E A Thomas; D J Kemp; K R Trenholme
Journal:  Mol Biochem Parasitol       Date:  2000-09       Impact factor: 1.759

2.  Dual stage synthesis and crucial role of cytoadherence-linked asexual gene 9 in the surface expression of malaria parasite var proteins.

Authors:  Suchi Goel; Manojkumar Valiyaveettil; Rajeshwara N Achur; Atul Goyal; Denise Mattei; Ali Salanti; Katharine R Trenholme; Donald L Gardiner; D Channe Gowda
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-07       Impact factor: 11.205

3.  Babesia and plasmodia increase host erythrocyte permeability through distinct mechanisms.

Authors:  Abdulnaser Alkhalil; David A Hill; Sanjay A Desai
Journal:  Cell Microbiol       Date:  2006-11-03       Impact factor: 3.715

4.  Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX).

Authors:  Hayley E Bullen; Sarah C Charnaud; Ming Kalanon; David T Riglar; Chaitali Dekiwadia; Niwat Kangwanrangsan; Motomi Torii; Takafumi Tsuboi; Jacob Baum; Stuart A Ralph; Alan F Cowman; Tania F de Koning-Ward; Brendan S Crabb; Paul R Gilson
Journal:  J Biol Chem       Date:  2012-01-17       Impact factor: 5.157

5.  Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites.

Authors:  Jose-Juan Lopez-Rubio; Liliana Mancio-Silva; Artur Scherf
Journal:  Cell Host Microbe       Date:  2009-02-19       Impact factor: 21.023

6.  Extracellular lysines on the plasmodial surface anion channel involved in Na+ exclusion.

Authors:  Jamieson V Cohn; Abdulnaser Alkhalil; Marissa A Wagner; Thavamani Rajapandi; Sanjay A Desai
Journal:  Mol Biochem Parasitol       Date:  2003-11       Impact factor: 1.759

7.  Characterization of permeation pathways in the plasma membrane of human erythrocytes infected with early stages of Plasmodium falciparum: association with parasite development.

Authors:  S Kutner; W V Breuer; H Ginsburg; S B Aley; Z I Cabantchik
Journal:  J Cell Physiol       Date:  1985-12       Impact factor: 6.384

8.  Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta.

Authors:  M Fried; P E Duffy
Journal:  Science       Date:  1996-06-07       Impact factor: 47.728

9.  Clag9 is not essential for PfEMP1 surface expression in non-cytoadherent Plasmodium falciparum parasites with a chromosome 9 deletion.

Authors:  Adéla Nacer; Emeric Roux; Sébastien Pomel; Christine Scheidig-Benatar; Hiroshi Sakamoto; Frank Lafont; Artur Scherf; Denise Mattei
Journal:  PLoS One       Date:  2011-12-19       Impact factor: 3.240

10.  The origin of parasitophorous vacuole membrane lipids in malaria-infected erythrocytes.

Authors:  G E Ward; L H Miller; J A Dvorak
Journal:  J Cell Sci       Date:  1993-09       Impact factor: 5.285
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  22 in total

Review 1.  The role of epigenetics and chromatin structure in transcriptional regulation in malaria parasites.

Authors:  Steven Abel; Karine G Le Roch
Journal:  Brief Funct Genomics       Date:  2019-09-24       Impact factor: 4.241

2.  Identification of Antimalarial Compounds That Require CLAG3 for Their Uptake by Plasmodium falciparum-Infected Erythrocytes.

Authors:  Sofía Mira-Martínez; Anastasia K Pickford; Núria Rovira-Graells; Alfred Cortés; Anna Rosanas-Urgell; Pieter Guetens; Elisabet Tintó-Font
Journal:  Antimicrob Agents Chemother       Date:  2019-04-25       Impact factor: 5.191

Review 3.  Epigenetics of malaria parasite nutrient uptake, but why?

Authors:  Sanjay A Desai
Journal:  Trends Parasitol       Date:  2022-05-28

4.  Plasmodium falciparum Clag9-Associated PfRhopH Complex Is Involved in Merozoite Binding to Human Erythrocytes.

Authors:  Bishwanath Kumar Chourasia; Arunaditya Deshmukh; Inderjeet Kaur; Gourab Paul; Ashutosh Panda; Sumit Rathore; Susheel K Singh; Michael Theisen; Asif Mohmmed; Pawan Malhotra
Journal:  Infect Immun       Date:  2020-01-22       Impact factor: 3.441

5.  Expression of the Plasmodium falciparum Clonally Variant clag3 Genes in Human Infections.

Authors:  Sofía Mira-Martínez; Evi van Schuppen; Alfred Amambua-Ngwa; Emmanuel Bottieau; Muna Affara; Marjan Van Esbroeck; Erika Vlieghe; Pieter Guetens; Núria Rovira-Graells; Gloria P Gómez-Pérez; Pedro L Alonso; Umberto D'Alessandro; Anna Rosanas-Urgell; Alfred Cortés
Journal:  J Infect Dis       Date:  2017-03-15       Impact factor: 5.226

6.  Deciphering the principles that govern mutually exclusive expression of Plasmodium falciparum clag3 genes.

Authors:  Núria Rovira-Graells; Valerie M Crowley; Cristina Bancells; Sofía Mira-Martínez; Lluís Ribas de Pouplana; Alfred Cortés
Journal:  Nucleic Acids Res       Date:  2015-07-21       Impact factor: 16.971

7.  Evidence of functional divergence in MSP7 paralogous proteins: a molecular-evolutionary and phylogenetic analysis.

Authors:  Diego Garzón-Ospina; Johanna Forero-Rodríguez; Manuel A Patarroyo
Journal:  BMC Evol Biol       Date:  2016-11-28       Impact factor: 3.260

8.  Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria.

Authors:  Zalak Shah; Myo T Naung; Kara A Moser; Matthew Adams; Andrea G Buchwald; Ankit Dwivedi; Amed Ouattara; Karl B Seydel; Don P Mathanga; Alyssa E Barry; David Serre; Miriam K Laufer; Joana C Silva; Shannon Takala-Harrison
Journal:  PLoS Genet       Date:  2021-05-25       Impact factor: 5.917

9.  Malaria Parasite CLAG3, a Protein Linked to Nutrient Channels, Participates in High Molecular Weight Membrane-Associated Complexes in the Infected Erythrocyte.

Authors:  Kayvan Zainabadi
Journal:  PLoS One       Date:  2016-06-14       Impact factor: 3.240

10.  Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach.

Authors:  Krishan Kumar; Prakash Srinivasan; Michael J Nold; J Kathleen Moch; Karine Reiter; Dan Sturdevant; Thomas D Otto; R Burke Squires; Raul Herrera; Vijayaraj Nagarajan; Julian C Rayner; Stephen F Porcella; Scott J Geromanos; J David Haynes; David L Narum
Journal:  Sci Rep       Date:  2017-12-07       Impact factor: 4.379
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