Augmentation of cysteamine-induced ulceration of rat duodenum by systemically administered gamma-aminobutyric acid (GABA).

Subcutaneous administration of a single dose of gamma-aminobutyric acid (GABA, 10 mg/100 g) in conjunction with a pretreatment dose of aminooxyacetic acid (AOAA 2.5 mg/100 g subcutaneously) to prevent the degradation of GABA, significantly augmented the incidence and intensity of cysteamine HCl-induced duodenal ulceration in rats. This effect of GABA could be reduced by the GABA receptor antagonist, bicuculline (30 micrograms/100 g subcutaneously). These results suggest peripheral GABA receptors can modulate cysteamine HCl-induced duodenal ulcer.