| Literature DB >> 25467162 |
Yang Su1, Lun Wu2, Qiuhong Wang3, Bingyou Yang2, Haixue Kuang4.
Abstract
Two new cycloartenol triterpene saponins, 3β,16α-dihydroxy-12-acetoxy-16,22-cyclo-23-ketone-24R,25-epoxy-cycloartane-3-O-β-D-galactopyranoside (1), 3β,16α-dihydroxy-12-acetoxy-16,22-cyclo-23-ketone-24R,25-epoxy-cycloartane-7-ene-3-O-β-D-xylopyranoside (2), were isolated from the ethyl acetate soluble fraction of the roots of Cimicifuga simplex Wormsk. Their structures were established by detailed spectroscopic analysis, including extensive 2D NMR data. Their anti-proinflammatory activities were also carried out by LPS-stimulated IL-6, IL-23 and TNF-α genes expression in RAW cells in vitro using Q-PCR method.Entities:
Keywords: 16,22-Cyclo-23-ketone type of cycloartane glycosides; Anti-inflammatory effect in vitro; The roots of Cimicifuga simplex Wormsk
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Year: 2014 PMID： 25467162 DOI： 10.1016/j.bmcl.2014.10.066
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823