Anna Pettersson1, Peter Nygren2, Christina Persson3, Anders Berglund4, Ingela Turesson5, Birgitta Johansson6. 1. Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden. Electronic address: anna.pettersson@onkologi.uu.se. 2. Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden. Electronic address: peter.nygren@medsci.uu.se. 3. Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden. Electronic address: rc.persson@telia.com. 4. Pfizer AB, Sollentuna, Sweden. Electronic address: ab@uppstat.se. 5. Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden. Electronic address: ingela.turesson@gmail.com. 6. Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden. Electronic address: birgitta.johansson@onkologi.uu.se.
Abstract
BACKGROUND AND PURPOSE: To evaluate the long-term effects of dietary intervention on gastrointestinal symptoms after highly dose-escalated radiotherapy for localized prostate cancer, using boost with protons or high-dose-rate brachytherapy. MATERIALS AND METHODS: Patients were randomized to an intervention group (n=64) advised to reduce insoluble dietary fiber and lactose intake, or to a standard care group (n=66) advised to continue their usual diet. Gastrointestinal symptoms, other domains of health-related quality of life (HRQOL), and dietary intake were evaluated for ⩽24months post-radiotherapy with the European Organization for Research and Treatment of Cancer quality-of-life questionnaires QLQ-C30 and QLQ-PR25, Gastrointestinal Side Effects Questionnaire, and Food Frequency Questionnaire. The effect of the intervention on gastrointestinal symptoms was evaluated using generalized estimating equations. RESULTS:Dietary intervention had no obvious effect on long-term gastrointestinal symptoms or HRQOL. The intervention group markedly reduced their dietary fiber and lactose intake during radiotherapy, but adherence tended to decline over time. The vast majority of long-term gastrointestinal symptoms were reported as 'a little', with a noticeable difference from pre-treatment only for unintentional stool leakage, limitations on daily activities, and mucus discharge. CONCLUSION: Long-term gastrointestinal symptoms were predominantly mild, and dietary intervention was not superior to a usual diet in preventing these symptoms.
RCT Entities:
BACKGROUND AND PURPOSE: To evaluate the long-term effects of dietary intervention on gastrointestinal symptoms after highly dose-escalated radiotherapy for localized prostate cancer, using boost with protons or high-dose-rate brachytherapy. MATERIALS AND METHODS:Patients were randomized to an intervention group (n=64) advised to reduce insoluble dietary fiber and lactose intake, or to a standard care group (n=66) advised to continue their usual diet. Gastrointestinal symptoms, other domains of health-related quality of life (HRQOL), and dietary intake were evaluated for ⩽24months post-radiotherapy with the European Organization for Research and Treatment of Cancer quality-of-life questionnaires QLQ-C30 and QLQ-PR25, Gastrointestinal Side Effects Questionnaire, and Food Frequency Questionnaire. The effect of the intervention on gastrointestinal symptoms was evaluated using generalized estimating equations. RESULTS: Dietary intervention had no obvious effect on long-term gastrointestinal symptoms or HRQOL. The intervention group markedly reduced their dietary fiber and lactose intake during radiotherapy, but adherence tended to decline over time. The vast majority of long-term gastrointestinal symptoms were reported as 'a little', with a noticeable difference from pre-treatment only for unintentional stool leakage, limitations on daily activities, and mucus discharge. CONCLUSION: Long-term gastrointestinal symptoms were predominantly mild, and dietary intervention was not superior to a usual diet in preventing these symptoms.
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