Mathieu Vergnat1, Alban-Elouen Baruteau2, Lucile Houyel3, Mohamedou Ly3, Régine Roussin3, André Capderou4, Virginie Lambert5, Emre Belli3. 1. Department of Pediatric and Congenital Heart Disease, Marie-Lannelongue Hospital-National Reference Center for Complex Cardiac Malformations-M3C, University of Paris-South, Le Plessis-Robinson, France. Electronic address: mvergnat@gmail.com. 2. Department of Pediatric and Congenital Heart Disease, Marie-Lannelongue Hospital-National Reference Center for Complex Cardiac Malformations-M3C, University of Paris-South, Le Plessis-Robinson, France; School of Medicine Paris-South, University Paris-South, Le Kremlin-Bicêtre, France. 3. Department of Pediatric and Congenital Heart Disease, Marie-Lannelongue Hospital-National Reference Center for Complex Cardiac Malformations-M3C, University of Paris-South, Le Plessis-Robinson, France. 4. School of Medicine Paris-South, University Paris-South, Le Kremlin-Bicêtre, France; INSERM U999, Marie-Lannelongue Hospital, Le Plessis Robinson, France. 5. Department of Pediatric and Congenital Heart Disease, Marie-Lannelongue Hospital-National Reference Center for Complex Cardiac Malformations-M3C, University of Paris-South, Le Plessis-Robinson, France; INSERM U999, Marie-Lannelongue Hospital, Le Plessis Robinson, France.
Abstract
OBJECTIVE: To assess the long-term results of the arterial switch operation (ASO) for Taussig-Bing Anomaly (TBA) and identify risk factors affecting outcomes. METHODS: Retrospective review and late follow-up was performed for all TBA patients from 1997 to 2010 (follow-up >3 years). Selection criteria included the absence of mitro-pulmonary continuity. RESULTS: Sixty-nine children underwent ASO at a median age of 24 days (interquartile range [IR] 11-125), with concomitant repair of aortic arch obstruction in 26 (37.7%). Complex coronary anatomy (n = 38; 55.0%) was common. Nine (13.0%) patients had staged repair. Hospital mortality was 5.8% (95% confidence interval [CI], 1.6%-14.2%; n = 4). Median follow-up was 11.2 years (IR 7.2-13.8). Subsequent mortality was confined to the first postoperative year (n = 5, 86% [95% CI, 78%-95%]), 1-, and 10-year survival). Overall mortality was related to coronary pattern (Yacoub types C and E vs A and D, multivariate, hazard ratio [HR] 12.2 [95% CI, 1.2-122.1], P = .03). At latest follow-up, 96% of the survivors are asymptomatic, with normal ventricular function. Cumulative incidence of reintervention at 10 years was 53% (95% CI, 28%-77%). Concomitant aortic arch obstruction was a predictor of reintervention (multivariate, HR 2.9 [95% CI, 1.1-7.4], P = .03). No mortality occurred upon reinterventions. CONCLUSIONS: In the largest series to date of ASO for TBA, mortality is confined to the first postoperative year, and related to coronary artery pattern. Beyond the first year, needed reinterventions are frequent, but with sustained functional status and no mortality over >10 years follow-up. Aortic arch obstruction is the main predictor for reintervention. Despite a significant rate of early events, favorable long-term outcomes argue for use of the ASO in TBA patients.
OBJECTIVE: To assess the long-term results of the arterial switch operation (ASO) for Taussig-Bing Anomaly (TBA) and identify risk factors affecting outcomes. METHODS: Retrospective review and late follow-up was performed for all TBA patients from 1997 to 2010 (follow-up >3 years). Selection criteria included the absence of mitro-pulmonary continuity. RESULTS: Sixty-nine children underwent ASO at a median age of 24 days (interquartile range [IR] 11-125), with concomitant repair of aortic arch obstruction in 26 (37.7%). Complex coronary anatomy (n = 38; 55.0%) was common. Nine (13.0%) patients had staged repair. Hospital mortality was 5.8% (95% confidence interval [CI], 1.6%-14.2%; n = 4). Median follow-up was 11.2 years (IR 7.2-13.8). Subsequent mortality was confined to the first postoperative year (n = 5, 86% [95% CI, 78%-95%]), 1-, and 10-year survival). Overall mortality was related to coronary pattern (Yacoub types C and E vs A and D, multivariate, hazard ratio [HR] 12.2 [95% CI, 1.2-122.1], P = .03). At latest follow-up, 96% of the survivors are asymptomatic, with normal ventricular function. Cumulative incidence of reintervention at 10 years was 53% (95% CI, 28%-77%). Concomitant aortic arch obstruction was a predictor of reintervention (multivariate, HR 2.9 [95% CI, 1.1-7.4], P = .03). No mortality occurred upon reinterventions. CONCLUSIONS: In the largest series to date of ASO for TBA, mortality is confined to the first postoperative year, and related to coronary artery pattern. Beyond the first year, needed reinterventions are frequent, but with sustained functional status and no mortality over >10 years follow-up. Aortic arch obstruction is the main predictor for reintervention. Despite a significant rate of early events, favorable long-term outcomes argue for use of the ASO in TBA patients.
Authors: Shada Al Anani; Ibtihaj Fughhi; Anas Taqatqa; Chawki Elzein; Michel N Ilbawi; Anastasios C Polimenakos Journal: Pediatr Cardiol Date: 2016-12-19 Impact factor: 1.655
Authors: Agata Bielecka-Dabrowa; Agata Bikiewicz; Marek Rybak; Filip Pawliczak; Joanna Lewek; Maciej Banach; Marek Maciejewski Journal: Clin Case Rep Date: 2021-12-06