Michael G Crooks1, Simon P Hart2. 1. Hull York Medical School, Academic Respiratory Medicine, Centre for Cardiovascular and Metabolic Research, Castle Hill Hospital, Cottingham HU16 5JQ, UK. 2. Hull York Medical School, Academic Respiratory Medicine, Centre for Cardiovascular and Metabolic Research, Castle Hill Hospital, Cottingham HU16 5JQ, UK. Electronic address: s.hart@hull.ac.uk.