| Literature DB >> 25466187 |
Norma Dunlap1, Tracy L J Salyard1, Anuradha Liyana Pathiranage1, Jeannie Stubblefield1, Steven L Pitts2, Rachel E Ashley2, Neil Osheroff2.
Abstract
A series of novel ether-linked dimers of demethylepipodophyllotoxin are topoisomerase II poisons that exhibit higher levels of double-stranded versus single-stranded DNA cleavage than their corresponding monomers. The dimers also have higher levels of tumor cell cytotoxicity than the monomers, lending support to the two-drug model for interaction of demethylepipodophyllotoxins with human topoisomerase IIα.Entities:
Keywords: Cytotoxicity; Demethylepipodophyllotoxin; Topoisomerase
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Year: 2014 PMID： 25466187 PMCID： PMC4425371 DOI： 10.1016/j.bmcl.2014.10.082
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823