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Literature DB >> 25465942

Categorical diagnosis: a fatal flaw for autism research?

Abstract

The use of autism as a diagnostic category guiding translational research is fraught with so many problems that the validity of research conclusions is suspect. Neuroscientists would benefit from attending to nosological difficulties to formulate meaningful research bridging basic biological systems and human disease. I propose a diagnostic schema that could translate more efficiently between the clinical and the neuroscience perspective as a step to improve the effectiveness of this type of research.

Entities: Disease Species

Keywords: autism; developmental disorder; diagnosis; psychiatric nosology; translational research

Mesh：

Year: 2014 PMID： 25465942 DOI： 10.1016/j.tins.2014.10.003

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

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Cited

9 in total

1. Autism and Epilepsy: Exploring the Relationship Using Experimental Models.

Authors: Carl E Stafstrom; Tim A Benke
Journal: Epilepsy Curr Date: 2015 Jul-Aug Impact factor: 7.500

2. Infant social attention: an endophenotype of ASD-related traits?

Authors: Emily J H Jones; Kaitlin Venema; Rachel K Earl; Rachel Lowy; Sara J Webb
Journal: J Child Psychol Psychiatry Date: 2016-11-08 Impact factor: 8.982

3. Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression.

Authors: Meghan E Carey; Juliette Rando; Stepan Melnyk; S Jill James; Nathaniel Snyder; Carolyn Salafia; Lisa A Croen; M Daniele Fallin; Irva Hertz-Picciotto; Heather Volk; Craig Newschaffer; Kristen Lyall
Journal: J Autism Dev Disord Date: 2022-06-09

4. Of decrements and disorders: assessing impairments in neurodevelopment in prospective studies of environmental toxicant exposures.

Authors: Sharon K Sagiv; Amy E Kalkbrenner; David C Bellinger
Journal: Environ Health Date: 2015-01-21 Impact factor: 5.984

Categorical diagnosis: a fatal flaw for autism research?

1. Autism and Epilepsy: Exploring the Relationship Using Experimental Models.

2. Infant social attention: an endophenotype of ASD-related traits?

3. Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression.

4. Of decrements and disorders: assessing impairments in neurodevelopment in prospective studies of environmental toxicant exposures.

Review 5. Perspectives on "Disease" and "Disability" in Child Health: The Case of Childhood Neurodisability.

6. Urinary Metabonomic Profiling Discriminates Between Children with Autism and Their Healthy Siblings.

7. Rethinking Our Concepts and Assumptions About Autism.

8. Classification of autistic individuals and controls using cross-task characterization of fMRI activity.

9. Altered Gamma Oscillations during Motor Control in Children with Autism Spectrum Disorder.