Jiuquan Zhang1, Luqing Wei2, Xiaofei Hu1, Bing Xie1, Yanling Zhang3, Guo-Rong Wu4, Jian Wang5. 1. Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China. 2. Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China. Electronic address: weiluqing1212@gmail.com. 3. Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China. 4. Key Laboratory of Personality and Cognition, Faculty of Psychology, Southwest University, Beibei, Chongqing 400715, PR China; Faculty of Psychology and Educational Sciences, Department of Data Analysis, Ghent University, Henri Dunantlaan 1, B-9000 Ghent, Belgium. 5. Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China. Electronic address: wangjian811@gmail.com.
Abstract
BACKGROUND: Parkinson's disease (PD) is a surprisingly heterogeneous neurodegenerative disorder. It is well established that different subtypes of PD present with different clinical courses and prognoses. However, the neural mechanism underlying these disparate presentations is uncertain. METHODS: Here we used resting-state fMRI (rs-fMRI) and the regional homogeneity (ReHo) method to determine neural activity patterns in the two main clinical subgroups of PD (akinetic-rigid and tremor-dominant). RESULTS: Compared with healthy controls, akinetic-rigid (AR) subjects had increased ReHo mainly in right amygdala, left putamen, bilateral angular gyrus, bilateral medial prefrontal cortex (MPFC), and decreased ReHo in left post cingulate gyrus/precuneus (PCC/PCu) and bilateral thalamus. In contrast, tremor-dominant (TD) patients showed higher ReHo mostly in bilateral angular gyrus, left PCC, cerebellum_crus1, and cerebellum_6, while ReHo was decreased in right putamen, primary sensory cortex (S1), vermis_3, and cerebellum_4_5. These results indicate that AR and TD subgroups both represent altered spontaneous neural activity in default-mode regions and striatum, and AR subjects exhibit more changed neural activity in the mesolimbic cortex (amygdala) but TD in the cerebellar regions. Of note, direct comparison of the two subgroups revealed a distinct ReHo pattern primarily located in the striatal-thalamo-cortical (STC) and cerebello-thalamo-cortical (CTC) loops. CONCLUSION: Overall, our findings highlight the involvement of default mode network (DMN) and STC circuit both in AR and TD subtypes, but also underscore the importance of integrating mesolimbic-striatal and CTC loops in understanding neural systems of akinesia and rigidity, as well as resting tremor in PD. This study provides improved understanding of the pathophysiological models of different subtypes of PD.
BACKGROUND:Parkinson's disease (PD) is a surprisingly heterogeneous neurodegenerative disorder. It is well established that different subtypes of PD present with different clinical courses and prognoses. However, the neural mechanism underlying these disparate presentations is uncertain. METHODS: Here we used resting-state fMRI (rs-fMRI) and the regional homogeneity (ReHo) method to determine neural activity patterns in the two main clinical subgroups of PD (akinetic-rigid and tremor-dominant). RESULTS: Compared with healthy controls, akinetic-rigid (AR) subjects had increased ReHo mainly in right amygdala, left putamen, bilateral angular gyrus, bilateral medial prefrontal cortex (MPFC), and decreased ReHo in left post cingulate gyrus/precuneus (PCC/PCu) and bilateral thalamus. In contrast, tremor-dominant (TD) patients showed higher ReHo mostly in bilateral angular gyrus, left PCC, cerebellum_crus1, and cerebellum_6, while ReHo was decreased in right putamen, primary sensory cortex (S1), vermis_3, and cerebellum_4_5. These results indicate that AR and TD subgroups both represent altered spontaneous neural activity in default-mode regions and striatum, and AR subjects exhibit more changed neural activity in the mesolimbic cortex (amygdala) but TD in the cerebellar regions. Of note, direct comparison of the two subgroups revealed a distinct ReHo pattern primarily located in the striatal-thalamo-cortical (STC) and cerebello-thalamo-cortical (CTC) loops. CONCLUSION: Overall, our findings highlight the involvement of default mode network (DMN) and STC circuit both in AR and TD subtypes, but also underscore the importance of integrating mesolimbic-striatal and CTC loops in understanding neural systems of akinesia and rigidity, as well as resting tremor in PD. This study provides improved understanding of the pathophysiological models of different subtypes of PD.
Authors: Jinhee Kim; Marion Criaud; Sang Soo Cho; María Díez-Cirarda; Alexander Mihaescu; Sarah Coakeley; Christine Ghadery; Mikaeel Valli; Mark F Jacobs; Sylvain Houle; Antonio P Strafella Journal: Brain Date: 2017-11-01 Impact factor: 13.501
Authors: Masoud Tahmasian; Simon B Eickhoff; Kathrin Giehl; Frank Schwartz; Damian M Herz; Alexander Drzezga; Thilo van Eimeren; Angela R Laird; Peter T Fox; Habibolah Khazaie; Mojtaba Zarei; Carsten Eggers; Claudia R Eickhoff Journal: Cortex Date: 2017-04-08 Impact factor: 4.027