Yanming Zhou1, Xiaoyi Lei2, Lupeng Wu2, Xiurong Wu2, Donghui Xu2, Bin Li2. 1. Department of Hepatobiliary & Pancreatovascular Surgery, First Affiliated Hospital of Xiamen University, Oncologic Center of Xiamen, Xiamen, China. Electronic address: zhouymsxy@sina.cn. 2. Department of Hepatobiliary & Pancreatovascular Surgery, First Affiliated Hospital of Xiamen University, Oncologic Center of Xiamen, Xiamen, China.
Abstract
BACKGROUND: Noncirrhotic hepatocellular carcinoma (HCC) is rare. The aim of this study was to evaluate the published evidence for hepatectomy in patients with noncirrhotic HCC. METHODS: A literature search was conducted in PubMed database for eligible studies from the time of inception to March 2014. Comparisons of surgical outcomes for noncirrhotic and cirrhotic HCC were pooled and analyzed by meta-analytical techniques. RESULTS: Thirty-one observational studies comprising a total of 3771 patients who underwent hepatectomy for noncirrhotic HCC were reviewed. The median postoperative morbidity was 29.5% (range, 8.3-55.5%) and mean mortality was 2.7% (range, 0-6.5%). Median 5-year overall and disease free survival was 47.9% (range, 26-81%) and 38.0% (range, 24.0-58.4%) respectively. In comparative studies, both the 5-year disease free (odds ratio (OR): 0.61, 95% confidence interval (95% CI): 0.51-0.72; P<0.001) and overall survival (OR: 0.61, 95% CI: 0.42-0.90; P=0.01) in the noncirrhotic group were significantly better than those in the cirrhotic group. CONCLUSIONS: Hepatectomy for noncirrhotic HCC carries low perioperative morbidity and mortality and offers favorable long-term outcomes.
BACKGROUND:Noncirrhotic hepatocellular carcinoma (HCC) is rare. The aim of this study was to evaluate the published evidence for hepatectomy in patients with noncirrhotic HCC. METHODS: A literature search was conducted in PubMed database for eligible studies from the time of inception to March 2014. Comparisons of surgical outcomes for noncirrhotic and cirrhotic HCC were pooled and analyzed by meta-analytical techniques. RESULTS: Thirty-one observational studies comprising a total of 3771 patients who underwent hepatectomy for noncirrhotic HCC were reviewed. The median postoperative morbidity was 29.5% (range, 8.3-55.5%) and mean mortality was 2.7% (range, 0-6.5%). Median 5-year overall and disease free survival was 47.9% (range, 26-81%) and 38.0% (range, 24.0-58.4%) respectively. In comparative studies, both the 5-year disease free (odds ratio (OR): 0.61, 95% confidence interval (95% CI): 0.51-0.72; P<0.001) and overall survival (OR: 0.61, 95% CI: 0.42-0.90; P=0.01) in the noncirrhotic group were significantly better than those in the cirrhotic group. CONCLUSIONS: Hepatectomy for noncirrhotic HCC carries low perioperative morbidity and mortality and offers favorable long-term outcomes.
Authors: Richard H Lewis; Evan S Glazer; David M Bittenbinder; Thomas O'Brien; Jeremiah L Deneve; David Shibata; Stephen W Behrman; Jason M Vanatta; Sanjaya K Satapathy; Paxton V Dickson Journal: J Gastrointest Cancer Date: 2019-12
Authors: Christopher Hadjittofi; Panagiotis G Athanasopoulos; Rahul S Koti; Sofia K Konstantinidou; Brian R Davidson Journal: Ann Transl Med Date: 2016-03
Authors: Kit-Fai Lee; Charing C N Chong; Anthony K W Fong; Andrew K Y Fung; Hon-Ting Lok; Yue-Sun Cheung; John Wong; Paul B S Lai Journal: Hepatobiliary Surg Nutr Date: 2018-10 Impact factor: 7.293