Literature DB >> 25465113

Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease.

Sapna Puri1, Alexandra E Folias1, Matthias Hebrok2.   

Abstract

Cellular identity is established by genetic, epigenetic, and environmental factors that regulate organogenesis and tissue homeostasis. Although some flexibility in fate potential is beneficial to overall organ health, dramatic changes in cellular identity can have disastrous consequences. Emerging data within the field of pancreas biology are revising current beliefs about how cellular identity is shaped by developmental and environmental cues under homeostasis and stress conditions. Here, we discuss the changes occurring in cellular states upon fate modulation and address how our understanding of the nature of this fluidity is shaping therapeutic approaches to pancreatic disorders such as diabetes and cancer.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25465113      PMCID： PMC4289422          DOI： 10.1016/j.stem.2014.11.001

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  121 in total

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Authors:  Timothy J Pullen; Gabriela da Silva Xavier; Gavin Kelsey; Guy A Rutter
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3.  Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas.

Authors:  Meritxell Rovira; Sherri-Gae Scott; Andrew S Liss; Jan Jensen; Sarah P Thayer; Steven D Leach
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-15       Impact factor: 11.205

4.  miR-375 maintains normal pancreatic alpha- and beta-cell mass.

Authors:  Matthew N Poy; Jean Hausser; Mirko Trajkovski; Matthias Braun; Stephan Collins; Patrik Rorsman; Mihaela Zavolan; Markus Stoffel
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-16       Impact factor: 11.205

5.  Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma.

Authors:  Janel L Kopp; Guido von Figura; Erin Mayes; Fen-Fen Liu; Claire L Dubois; John P Morris; Fong Cheng Pan; Haruhiko Akiyama; Christopher V E Wright; Kristin Jensen; Matthias Hebrok; Maike Sander
Journal:  Cancer Cell       Date:  2012-11-29       Impact factor: 31.743

6.  Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.

Authors:  Chutima Talchai; Shouhong Xuan; Hua V Lin; Lori Sussel; Domenico Accili
Journal:  Cell       Date:  2012-09-14       Impact factor: 41.582

7.  The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.

Authors:  Christophe E Pierreux; Aurélie V Poll; Caroline R Kemp; Frédéric Clotman; Miguel A Maestro; Sabine Cordi; Jorge Ferrer; Luc Leyns; Guy G Rousseau; Frédéric P Lemaigre
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8.  Notch signaling is required for exocrine regeneration after acute pancreatitis.

Authors:  Jens T Siveke; Clara Lubeseder-Martellato; Marcel Lee; Pawel K Mazur; Hassan Nakhai; Freddy Radtke; Roland M Schmid
Journal:  Gastroenterology       Date:  2007-11-04       Impact factor: 22.682

9.  beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes.

Authors:  U Ahlgren; J Jonsson; L Jonsson; K Simu; H Edlund
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10.  In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

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Journal:  Nature       Date:  2008-08-27       Impact factor: 49.962
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  63 in total

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Journal:  J Dent Res       Date:  2015-08-18       Impact factor: 6.116

Review 2.  Dedifferentiated fat cells: A cell source for regenerative medicine.

Authors:  Medet Jumabay; Kristina I Boström
Journal:  World J Stem Cells       Date:  2015-11-26       Impact factor: 5.326

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4.  Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.

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Journal:  Cell Stem Cell       Date:  2016-04-07       Impact factor: 24.633

5.  CRISPR-on system for the activation of the endogenous human INS gene.

Authors:  C A Giménez; M Ielpi; A Mutto; L Grosembacher; P Argibay; F Pereyra-Bonnet
Journal:  Gene Ther       Date:  2016-04-04       Impact factor: 5.250

Review 6.  Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract.

Authors:  Jason C Mills; Owen J Sansom
Journal:  Sci Signal       Date:  2015-07-14       Impact factor: 8.192

Review 7.  Oncogenic KRAS and the EGFR loop in pancreatic carcinogenesis-A connection to licensing nodes.

Authors:  Christian Schneeweis; Matthias Wirth; Dieter Saur; Maximilian Reichert; Günter Schneider
Journal:  Small GTPases       Date:  2017-01-20

Review 8.  Adult Pancreatic Acinar Progenitor-like Populations in Regeneration and Cancer.

Authors:  Zhengyu Jiang; Ruth A White; Timothy C Wang
Journal:  Trends Mol Med       Date:  2020-04-30       Impact factor: 11.951

Review 9.  Metabolism and epigenetics of pancreatic cancer stem cells.

Authors:  M Perusina Lanfranca; J K Thompson; F Bednar; C Halbrook; C Lyssiotis; B Levi; T L Frankel
Journal:  Semin Cancer Biol       Date:  2018-09-28       Impact factor: 15.707

10.  Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.

Authors:  Chinh Q Hoang; Michael A Hale; Ana C Azevedo-Pouly; Hans P Elsässer; Tye G Deering; Spencer G Willet; Fong C Pan; Mark A Magnuson; Christopher V E Wright; Galvin H Swift; Raymond J MacDonald
Journal:  Mol Cell Biol       Date:  2016-11-28       Impact factor: 4.272
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