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Literature DB >> 25465042

The role of the spleen in ischemic stroke.

Abstract

This opinion piece highlights the scientific literature reporting that the peripheral immune response to ischemic stroke originates from the spleen. Removal of the spleen not only reduces stroke-induced neurodegeneration but also cellular degeneration in the body's other tissues when exposed to ischemic conditions.

Entities: Disease

Mesh：

Year: 2014 PMID： 25465042 PMCID： PMC4426754 DOI： 10.1038/jcbfm.2014.212

Source DB: PubMed Journal: J Cereb Blood Flow Metab ISSN： 0271-678X Impact factor: 6.200

20 in total

Review 1. Reactive oxygen and mechanisms of inflammatory liver injury.

Authors: H Jaeschke
Journal: J Gastroenterol Hepatol Date: 2000-07 Impact factor: 4.029

2. Role of spleen-derived monocytes/macrophages in acute ischemic brain injury.

Authors: Eunhee Kim; Jiwon Yang; Cesar D Beltran; Sunghee Cho
Journal: J Cereb Blood Flow Metab Date: 2014-05-28 Impact factor: 6.200

Review 3. Therapeutic approaches for ischemia/reperfusion injury in the liver.

Authors: C Fan; R M Zwacka; J F Engelhardt
Journal: J Mol Med (Berl) Date: 1999-08 Impact factor: 4.599

4. Splenectomy-reduced hepatic injury induced by ischemia/reperfusion in the rat.

Authors: Y Okuaki; H Miyazaki; M Zeniya; T Ishikawa; Y Ohkawa; S Tsuno; M Sakaguchi; M Hara; H Takahashi; G Toda
Journal: Liver Date: 1996-06

5. Acute splenic irradiation reduces brain injury in the rat focal ischemic stroke model.

Authors: Robert P Ostrowski; Reinhard W Schulte; Ying Nie; Ted Ling; Timothy Lee; Anatol Manaenko; Daila S Gridley; John H Zhang
Journal: Transl Stroke Res Date: 2012-12 Impact factor: 6.829

6. Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages.

Authors: Halina Offner; Sandhya Subramanian; Susan M Parker; Chunhe Wang; Michael E Afentoulis; Anne Lewis; Arthur A Vandenbark; Patricia D Hurn
Journal: J Immunol Date: 2006-06-01 Impact factor: 5.422

7. Cord blood rescues stroke-induced changes in splenocyte phenotype and function.

Authors: Martina Vendrame; Carmelina Gemma; Keith R Pennypacker; Paula C Bickford; Cyndy Davis Sanberg; Paul R Sanberg; Alison E Willing
Journal: Exp Neurol Date: 2006-05-19 Impact factor: 5.330

8. The spleen contributes to stroke-induced neurodegeneration.

Authors: Craig T Ajmo; Dionne O L Vernon; Lisa Collier; Aaron A Hall; Svitlana Garbuzova-Davis; Alison Willing; Keith R Pennypacker
Journal: J Neurosci Res Date: 2008-08-01 Impact factor: 4.164

9. Splenectomy protects experimental rats from cerebral damage after stroke due to anti-inflammatory effects.

Authors: Bing-Jun Zhang; Xue-Jiao Men; Zheng-Qi Lu; Hai-Yan Li; Wei Qiu; Xue-Qiang Hu
Journal: Chin Med J (Engl) Date: 2013-06 Impact factor: 2.628

10. Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats.

Authors: Mahasweta Das; Christopher C Leonardo; Saniya Rangooni; Keith R Pennypacker; Subhra Mohapatra; Shyam S Mohapatra
Journal: J Neuroinflammation Date: 2011-10-31 Impact factor: 8.322

23 in total

1. Acute splenic responses in patients with ischemic stroke and intracerebral hemorrhage.

Authors: Farhaan S Vahidy; Kaushik N Parsha; Mohammad H Rahbar; MinJae Lee; Thanh-Tung Bui; Claude Nguyen; Andrew D Barreto; Arvind B Bambhroliya; Preeti Sahota; Bing Yang; Jaroslaw Aronowski; Sean I Savitz
Journal: J Cereb Blood Flow Metab Date: 2015-10-02 Impact factor: 6.200

The role of the spleen in ischemic stroke.

Review 1. Reactive oxygen and mechanisms of inflammatory liver injury.

2. Role of spleen-derived monocytes/macrophages in acute ischemic brain injury.

Review 3. Therapeutic approaches for ischemia/reperfusion injury in the liver.

4. Splenectomy-reduced hepatic injury induced by ischemia/reperfusion in the rat.

5. Acute splenic irradiation reduces brain injury in the rat focal ischemic stroke model.

6. Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages.

7. Cord blood rescues stroke-induced changes in splenocyte phenotype and function.

8. The spleen contributes to stroke-induced neurodegeneration.

9. Splenectomy protects experimental rats from cerebral damage after stroke due to anti-inflammatory effects.

10. Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats.

1. Acute splenic responses in patients with ischemic stroke and intracerebral hemorrhage.

Review 2. Systemic inflammation in hemorrhagic strokes - A novel neurological sign and therapeutic target?

Review 3. Developing Cellular Therapies for Stroke.

4. Experimental ischemic stroke induces long-term T cell activation in the brain.

Review 5. Is Immunomodulation a Principal Mechanism Underlying How Cell-Based Therapies Enhance Stroke Recovery?

Review 6. Sex differences in the immune response to experimental stroke: Implications for translational research.

Review 7. Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair.

8. Upregulation of CD74 and its potential association with disease severity in subjects with ischemic stroke.

Review 9. Partial MHC class II constructs as novel immunomodulatory therapy for stroke.

10. Emerging potential of exosomes and noncoding microRNAs for the treatment of neurological injury/diseases.