| Literature DB >> 25464888 |
Oytun Erbaş1, Bilge Piri Çınar2, Volkan Solmaz3, Türker Çavuşoğlu4, Utku Ateş4.
Abstract
Dopaminergic neuronal loss in Parkinson's disease (PD) results from oxidative stress, neuroinflammation and excitotoxicity. Because erythropoietin (EPO) has been shown to have antioxidant, anti-inflammatory and neuroprotective effects in many previous studies, present study was designed to evaluate the effect of EPO on rotenone-induced dopaminergic neuronal loss. The rats in which PD was induced by stereotaxical infusion of rotenone showed increased MDA and TNF-alpha levels and decreased HVA levels. On the other hand, EPO treatment resulted in markedly decreased MDA and TNF-alpha levels and increased HVA levels. EPO treatment in rotenone-infusion group resulted in improvement of striatal neurodegeneration and a significant increase in decreased total number of neurons and immunohistochemical TH positive neurons. Results of the present study demonstrate the neuroprotective, anti-inflammatory and antioxidant effects of EPO in a rotenone-induced neurodegenerative animal model.Entities:
Keywords: Erythropoietin; Inflammation; Neuronal cell loss; Neuroprotection; Rotenone
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Year: 2014 PMID： 25464888 DOI： 10.1016/j.npep.2014.10.003
Source DB: PubMed Journal: Neuropeptides ISSN： 0143-4179 Impact factor: 3.286