Literature DB >> 25463612

Six1 overexpression at early stages of HPV16-mediated transformation of human keratinocytes promotes differentiation resistance and EMT.

Hanwen Xu1, Lucia Pirisi2, Kim E Creek3.   

Abstract

Previous studies in our laboratory discovered that SIX1 mRNA expression increased during in vitro progression of HPV16-immortalized human keratinocytes (HKc/HPV16) toward a differentiation-resistant (HKc/DR) phenotype. In this study, we explored the role of Six1 at early stages of HPV16-mediated transformation by overexpressing Six1 in HKc/HPV16. We found that Six1 overexpression in HKc/HPV16 increased cell proliferation and promoted cell migration and invasion by inducing epithelial-mesenchymal transition (EMT). Moreover, the overexpression of Six1 in HKc/HPV16 resulted in resistance to serum and calcium-induced differentiation, which is the hallmark of the HKc/DR phenotype. Activation of MAPK in HKc/HPV16 overexpressing Six1 is linked to resistance to calcium-induced differentiation. In conclusion, this study determined that Six1 overexpression resulted in differentiation resistance and promoted EMT at early stages of HPV16-mediated transformation of human keratinocytes.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cervical cancer; Differentiation resistance; Epithelial–mesenchymal transition; Human papillomavirus; MAPK; Six1

Mesh：

Substances：

Year:  2014        PMID： 25463612      PMCID： PMC4259858          DOI： 10.1016/j.virol.2014.10.010

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  48 in total

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10.  Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA.

Authors:  L Pirisi; K E Creek; J Doniger; J A DiPaolo
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  6 in total

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