Rehan Malik1, Ehimen C Aneni2, Lara Roberson1, Oluseye Ogunmoroti1, Shozab S Ali3, Sameer Shaharyar4, Adnan Younus1, Omar Jamal1, Muhammad A Aziz1, Seth S Martin5, Michael J Blaha5, Theodore Feldman1, Arthur S Agatston1, Emir Veledar6, Khurram Nasir7. 1. Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami, FL, USA. 2. Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami, FL, USA. Electronic address: ehimena@baptisthealth.net. 3. Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami, FL, USA; University of Manchester School of Medicine, Manchester, United Kingdom. 4. Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami, FL, USA; Aventura Hospital and Medical Center, Aventura, Florida. 5. Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD, USA. 6. Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami, FL, USA; Robert Stempel College of Public Health, Florida International University, Miami, FL, USA. 7. Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami, FL, USA; Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD, USA; Robert Stempel College of Public Health, Florida International University, Miami, FL, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Abstract
OBJECTIVES: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). METHODS: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. RESULTS: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. CONCLUSION: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.
OBJECTIVES: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC). METHODS: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria. RESULTS: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent. CONCLUSION: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.
Authors: Vincent L Aengevaeren; Arend Mosterd; Sanjay Sharma; Niek H J Prakken; Stefan Möhlenkamp; Paul D Thompson; Birgitta K Velthuis; Thijs M H Eijsvogels Journal: Circulation Date: 2020-04-20 Impact factor: 29.690
Authors: Nonanzit Pérez-Hernández; Gad Aptilon-Duque; María Cristina Nostroza-Hernández; Gilberto Vargas-Alarcón; José Manuel Rodríguez-Pérez; Ruben Blachman-Braun Journal: Korean J Intern Med Date: 2016-04-27 Impact factor: 2.884