Thomas Gremmel1, Christoph W Kopp2, Beate Eichelberger3, Renate Koppensteiner2, Simon Panzer3. 1. Division of Angiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria. Electronic address: thomas.gremmel@meduniwien.ac.at. 2. Division of Angiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria. 3. Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
Abstract
OBJECTIVE: To investigate differences of platelet activation and on-treatment residual platelet reactivity between female and male patients with atherosclerotic cardiovascular disease. METHODS: We compared P-selectin expression, activated glycoprotein (GP) IIb/IIIa and leukocyte-platelet aggregates (LPA) by flow cytometry between 110 female and 206 male patients undergoing angioplasty and stenting. On-treatment residual platelet reactivity was determined by two test systems. RESULTS: The expression of P-selectin and GPIIb/IIIa did not differ significantly between female and male patients. In contrast, females showed a significantly more pronounced formation of LPA in vivo, in response to thrombin receptor-activating peptide-6 and in response to adenosine diphosphate. Further, high LPA were seen more frequently in female patients. Finally, protease-activated receptor (PAR)-1 mediated platelet reactivity by both assays was significantly higher in females. CONCLUSION: Female sex is associated with a more pronounced formation of LPA and increased PAR-1 mediated platelet reactivity in atherosclerotic cardiovascular disease.
OBJECTIVE: To investigate differences of platelet activation and on-treatment residual platelet reactivity between female and male patients with atherosclerotic cardiovascular disease. METHODS: We compared P-selectin expression, activated glycoprotein (GP) IIb/IIIa and leukocyte-platelet aggregates (LPA) by flow cytometry between 110 female and 206 male patients undergoing angioplasty and stenting. On-treatment residual platelet reactivity was determined by two test systems. RESULTS: The expression of P-selectin and GPIIb/IIIa did not differ significantly between female and male patients. In contrast, females showed a significantly more pronounced formation of LPA in vivo, in response to thrombin receptor-activating peptide-6 and in response to adenosine diphosphate. Further, high LPA were seen more frequently in female patients. Finally, protease-activated receptor (PAR)-1 mediated platelet reactivity by both assays was significantly higher in females. CONCLUSION: Female sex is associated with a more pronounced formation of LPA and increased PAR-1 mediated platelet reactivity in atherosclerotic cardiovascular disease.
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