Murat Sunbul1, Mehmet Agirbasli1, Erdal Durmus2, Tarik Kivrak3, Hakan Akin4, Yucel Aydin4, Rabia Ergelen5, Yusuf Yilmaz6. 1. Department of Cardiology, School of Medicine, Marmara University, Istanbul, Turkey. 2. Cardiology Clinic, Silifke State Hospital, Mersin, Turkey. 3. Cardiology Clinic, Sivas Numune Hospital, Sivas, Turkey. 4. Department of Gastroenterology, School of Medicine, Marmara University, Fevzi Cakmak Mah, Mimar Sinan Cad. No. 41 Ust Kaynarca, Pendik, Istanbul, Turkey. 5. Department of Radiology, School of Medicine, Marmara University, Istanbul, Turkey. 6. Department of Gastroenterology, School of Medicine, Marmara University, Fevzi Cakmak Mah, Mimar Sinan Cad. No. 41 Ust Kaynarca, Pendik, Istanbul, Turkey; Institute of Gastroenterology, Marmara University, Basibuyuk, Maltepe, Istanbul 34840, Turkey. Electronic address: dryusufyilmaz@gmail.com.
Abstract
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is associated with atherosclerosis and reduced vascular compliance. The purpose of this study was to examine the relationships between arterial stiffness measures, the histological severity of NAFLD, and epicardial fat thickness (EFT). METHODS: A total of 100 patients with biopsy-proven NAFLD and 50 age- and sex-matched controls were enrolled. The histological severity was assessed in all NAFLD patients. Measurements of arterial stiffness [pulse-wave velocity (PWV) and augmentation index (AIx)] were carried out using a Mobil-O-Graph arteriograph system. EFT was assessed by means of echocardiography. RESULTS: Compared with controls, NAFLD patients had significantly higher PWV and AIx values. Stepwise linear regression analysis demonstrated that the liver fibrosis score and EFT were independent predictors of both PWV and AIx values in NAFLD patients. CONCLUSIONS: Patients with NAFLD have an increased arterial stiffness, which reflects both the severity of liver fibrosis and increased EFT values.
OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is associated with atherosclerosis and reduced vascular compliance. The purpose of this study was to examine the relationships between arterial stiffness measures, the histological severity of NAFLD, and epicardial fat thickness (EFT). METHODS: A total of 100 patients with biopsy-proven NAFLD and 50 age- and sex-matched controls were enrolled. The histological severity was assessed in all NAFLD patients. Measurements of arterial stiffness [pulse-wave velocity (PWV) and augmentation index (AIx)] were carried out using a Mobil-O-Graph arteriograph system. EFT was assessed by means of echocardiography. RESULTS: Compared with controls, NAFLD patients had significantly higher PWV and AIx values. Stepwise linear regression analysis demonstrated that the liver fibrosis score and EFT were independent predictors of both PWV and AIx values in NAFLD patients. CONCLUSIONS:Patients with NAFLD have an increased arterial stiffness, which reflects both the severity of liver fibrosis and increased EFT values.
Authors: Young Dae Kim; Dongbeom Song; Ji Hoe Heo; Seung Up Kim; Beom Kyung Kim; Jun Yong Park; Do Young Kim; Sang Hoon Ahn; Kwang Joon Kim; Kwang-Hyub Han Journal: PLoS One Date: 2015-09-30 Impact factor: 3.240
Authors: Cristiane A Villela-Nogueira; Nathalie C Leite; Claudia R L Cardoso; Gil F Salles Journal: Int J Mol Sci Date: 2016-04-20 Impact factor: 5.923