Anatomically weighted second-order total variation reconstruction of 23Na MRI using prior information from 1H MRI.

Sodium ((23)Na) MRI is a noninvasive tool to assess cell viability, which is linked to the total tissue sodium concentration (TSC). However, due to low in vivo concentrations, (23)Na MRI suffers from low signal-to-noise ratio (SNR) and limited spatial resolution. As a result, image quality is compromised by Gibbs ringing artifacts and partial volume effects. An iterative reconstruction algorithm that incorporates prior information from (1)H MRI is developed to reduce partial volume effects and to increase the SNR in non-proton MRI. Anatomically weighted second-order total variation (AnaWeTV) is proposed as a constraint for compressed sensing reconstruction of 3D projection reconstruction (3DPR) data. The method is evaluated in simulations and a MR measurement of a multiple sclerosis (MS) patient by comparing it to gridding and other reconstruction techniques. AnaWeTV increases resolution of known structures and reduces partial volume effects. In simulated MR brain data (nominal resolution Δx(3) = 3 × 3 × 3 mm(3)), the intensity error of four small MS lesions was reduced from (6.9 ± 3.8)% (gridding) to (2.8 ± 1.4)% (AnaWeTV with T2-weighted reference images). Compared to gridding, a substantial SNR increase of 130% was found in the white matter of the MS patient. The algorithm is robust against misalignment of the prior information on the order of the (23)Na image resolution. Features without prior information are still reconstructed with high contrast. AnaWeTV allows a more precise quantification of TSC in structures with prior knowledge. Thus, the AnaWeTV algorithm is in particular beneficial for the assessment of tissue structures that are visible in both (23)Na and (1)H MRI.