| Literature DB >> 25462595 |
Florian Reinhart1, Nabil El Massri2, Fannie Darlot3, Napoleon Torres4, Daniel M Johnstone5, Claude Chabrol6, Thomas Costecalde7, Jonathan Stone8, John Mitrofanis9, Alim-Louis Benabid10, Cécile Moro11.
Abstract
We explored whether 810nm near-infrared light (NIr) offered neuroprotection and/or improvement in locomotor activity in an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse model of Parkinson's disease. Mice received MPTP and 810nm NIr treatments, or not, and were tested for locomotive activity in an open-field test. Thereafter, brains were aldehyde-fixed and processed for tyrosine hydroxylase immunohistochemistry. Our results showed that MPTP-treated mice that were irradiated with 810nm NIr had both greater locomotor activity (∼40%) and number of dopaminergic cells (∼20%) than those that were not. In summary, 810nm (as with 670nm) NIr offered neuroprotection and improved locomotor activity in MPTP-treated mice.Entities:
Keywords: Neuroprotection; Substantia nigra; Tyrosine hydroxylase
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Year: 2014 PMID： 25462595 DOI： 10.1016/j.neures.2014.11.005
Source DB: PubMed Journal: Neurosci Res ISSN： 0168-0102 Impact factor: 2.904