| Literature DB >> 25462579 |
Massimo Costanza1, Nadine Binart2, Lawrence Steinman3, Rosetta Pedotti4.
Abstract
Prolactin (PRL) has long been proposed as an immune-stimulating and detrimental factor in autoimmune disorders. However, recent findings have challenged this common view, showing that PRL does not play a crucial role in the development of experimental autoimmune encephalomyelitis, animal model for multiple sclerosis (MS), and even protects against adjuvant-induced model of rheumatoid arthritis (RA). In this review we provide a critical overview of data supporting a role for PRL in the regulation of immune responses. In addition, we focus on studies exploring the involvement of PRL in autoimmune diseases, such as systemic lupus erythematosus, MS and RA, in light of the recently-outlined regenerative properties of this hormone.Entities:
Keywords: Inflammation; Multiple sclerosis; Prolactin; Rheumatoid arthritis; Systemic lupus erythematosus; Tissue repair
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Year: 2014 PMID： 25462579 DOI： 10.1016/j.autrev.2014.11.005
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754