Literature DB >> 25462242

Benzodioxane-benzamides as new bacterial cell division inhibitors.

Giuseppe Chiodini1, Marco Pallavicini1, Carlo Zanotto2, Massimiliano Bissa3, Antonia Radaelli4, Valentina Straniero1, Cristiano Bolchi1, Laura Fumagalli1, Paola Ruggeri1, Carlo De Giuli Morghen5, Ermanno Valoti6.   

Abstract

A SAR study was performed on 3-substituted 2,6-difluorobenzamides, known inhibitors of the essential bacterial cell division protein FtsZ, through a series of modifications first of 2,6-difluoro-3-nonyloxybenzamide and then of its 3-pyridothiazolylmethoxy analogue PC190723. The study led to the identification of chiral 2,6-difluorobenzamides bearing 1,4-benzodioxane-2-methyl residue at the 3-position as potent antistaphylococcal compounds.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  2,6-Difluorobenzamide; Antibacterial activity; Benzodioxane; FtsZ; Staphylococcus aureus

Mesh：

Substances：

Year:  2014        PMID： 25462242     DOI： 10.1016/j.ejmech.2014.09.100

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  6 in total

1.  Computational Design and Development of Benzodioxane-Benzamides as Potent Inhibitors of FtsZ by Exploring the Hydrophobic Subpocket.

Authors:  Valentina Straniero; Victor Sebastián-Pérez; Lorenzo Suigo; William Margolin; Andrea Casiraghi; Martina Hrast; Carlo Zanotto; Irena Zdovc; Antonia Radaelli; Ermanno Valoti
Journal:  Antibiotics (Basel)       Date:  2021-04-15

2.  Antimicrobial Action and Reversal of Resistance in MRSA by Difluorobenzamide Derivatives Targeted at FtsZ.

Authors:  Wern Chern Chai; Jonathan J Whittall; Di Song; Steven W Polyak; Abiodun D Ogunniyi; Yinhu Wang; Fangchao Bi; Shutao Ma; Susan J Semple; Henrietta Venter
Journal:  Antibiotics (Basel)       Date:  2020-12-05

Review 3.  Terminal Phenoxy Group as a Privileged Moiety of the Drug Scaffold-A Short Review of Most Recent Studies 2013-2022.

Authors:  Paweł Kozyra; Monika Pitucha
Journal:  Int J Mol Sci       Date:  2022-08-09       Impact factor: 6.208

4.  Resolution via diastereomeric amides of enantiopure 1,4-benzoxathian-2- and 3-carboxylic acids and determination of their configuration.

Authors:  Valentina Straniero; Giulia Lodigiani; Lorenzo Suigo; Ermanno Valoti
Journal:  Chirality       Date:  2022-05-20       Impact factor: 2.183

5.  Structural Variations in the Central Heterocyclic Scaffold of Tripartite 2,6-Difluorobenzamides: Influence on Their Antibacterial Activity against MDR Staphylococcus aureus.

Authors:  Thibaut Barbier; Cédric Badiou; Floriane Davy; Yves Queneau; Oana Dumitrescu; Gérard Lina; Laurent Soulère
Journal:  Molecules       Date:  2022-10-05       Impact factor: 4.927

6.  Benzamide Derivatives Targeting the Cell Division Protein FtsZ: Modifications of the Linker and the Benzodioxane Scaffold and Their Effects on Antimicrobial Activity.

Authors:  Valentina Straniero; Lorenzo Suigo; Andrea Casiraghi; Victor Sebastián-Pérez; Martina Hrast; Carlo Zanotto; Irena Zdovc; Carlo De Giuli Morghen; Antonia Radaelli; Ermanno Valoti
Journal:  Antibiotics (Basel)       Date:  2020-04-04
  6 in total

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