Literature DB >> 2546106

Experimental ischemia induces a persistent depolarization blocked by decreased calcium and NMDA antagonists.

R K Rader1, T H Lanthorn.   

Abstract

Early physiological events induced by hypoxia plus low D-glucose were investigated by intracellular recording in the rat hippocampal slice. A rapid intracellular depolarization corresponded to the extracellularly recorded anoxic depolarization. This intracellular depolarization consisted of two pharmacologically distinct components, an initial depolarization and a persistent depolarization. The persistent phase of depolarization was selectively blocked by lowering calcium and raising magnesium and by N-methyl-D-aspartate (NMDA) antagonists. This persistent depolarization can account for the long-term synaptic failure seen following experimental ischemia in vitro.

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Year:  1989        PMID： 2546106     DOI： 10.1016/0304-3940(89)90276-0

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  13 in total

1.  A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells.

Authors:  Nicola J Allen; Ragnhildur Káradóttir; David Attwell
Journal:  J Neurosci       Date:  2005-01-26       Impact factor: 6.167

Review 2.  Pannexin channels and ischaemia.

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Journal:  Mol Ther       Date:  2009-03-17       Impact factor: 11.454

4.  NMDA antagonists increase recovery of evoked potentials from slices of rat olfactory cortex after anoxia.

Authors:  M Yassin; C N Scholfield
Journal:  Br J Pharmacol       Date:  1994-04       Impact factor: 8.739

Review 5.  Hyperglycemia / hypoglycemia-induced mitochondrial dysfunction and cerebral ischemic damage in diabetics.

Authors:  Ashish K Rehni; Neha Nautiyal; Miguel A Perez-Pinzon; Kunjan R Dave
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6.  Influence of hypoxia on excitation and GABAergic inhibition in mature and developing rat neocortex.

Authors:  H J Luhmann; T Kral; U Heinemann
Journal:  Exp Brain Res       Date:  1993       Impact factor: 1.972

7.  Seizure activity in the rat hippocampus, perirhinal and prefrontal cortex associated with transient global cerebral ischemia.

Authors:  D A Caruana; C Nesbitt; D G Mumby; C A Chapman
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8.  Contribution of astrocyte glycogen stores to progression of spreading depression and related events in hippocampal slices.

Authors:  J L Seidel; C W Shuttleworth
Journal:  Neuroscience       Date:  2011-05-12       Impact factor: 3.590

Review 9.  Contributions of Ca2+ and Zn2+ to spreading depression-like events and neuronal injury.

Authors:  Robert M Dietz; John H Weiss; C William Shuttleworth
Journal:  J Neurochem       Date:  2009-05       Impact factor: 5.372

10.  Zn2+ influx is critical for some forms of spreading depression in brain slices.

Authors:  Robert M Dietz; John H Weiss; Claude W Shuttleworth
Journal:  J Neurosci       Date:  2008-08-06       Impact factor: 6.167
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