Todd P Whitehead1, Sabrina Crispo Smith2, June-Soo Park3, Myrto X Petreas4, Stephen M Rappaport5, Catherine Metayer6. 1. School of Public Health, University of California Berkeley, 50 University Hall, Berkeley, CA 94720, USA. Electronic address: ToddPWhitehead@Berkeley.edu. 2. Environmental Chemistry Laboratory, California Department of Toxic Substances Control, 700 Heinz Ave, Berkeley, CA 94710, USA; Sequoia Foundation, 2166 Avenida De La Playa, La Jolla, CA 92037, USA. Electronic address: Sabrina.CrispoSmith@DTSC.CA.gov. 3. Environmental Chemistry Laboratory, California Department of Toxic Substances Control, 700 Heinz Ave, Berkeley, CA 94710, USA. Electronic address: June-Soo.Park@DTSC.CA.gov. 4. Environmental Chemistry Laboratory, California Department of Toxic Substances Control, 700 Heinz Ave, Berkeley, CA 94710, USA. Electronic address: Myrto.Petreas@DTSC.CA.gov. 5. School of Public Health, University of California Berkeley, 50 University Hall, Berkeley, CA 94720, USA. Electronic address: SRappaport@Berkeley.edu. 6. School of Public Health, University of California Berkeley, 50 University Hall, Berkeley, CA 94720, USA. Electronic address: CMetayer@Berkeley.edu.
Abstract
BACKGROUND: Humans are exposed to persistent organic pollutants (POPs) through various routes, including consumption of contaminated food and accidental ingestion of settled dust. OBJECTIVES: We aimed to identify key routes of exposure to organochlorine pesticides, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) in California women of reproductive age. METHODS: Blood was collected from 48 mothers participating in the California Childhood Leukemia Study from 2006 to 2007 and analyzed for POPs using gas chromatography-mass spectrometry. Multivariable linear regression models of natural-log transformed serum concentrations were used to identify determinants of exposure from available questionnaire information on dietary habits, reproductive history, and demographic characteristics, as well as vacuum cleaner dust-POP levels. RESULTS: After adjusting for blood lipid levels, age, body mass index, cumulative lactation, and sampling date, serum concentrations of multiple major PCBs were positively associated with fish consumption, but not dust-PCB levels. After adjusting for blood lipid levels, Hispanic ethnicity, country of origin, and household annual income, serum concentrations of multiple major PBDEs were positively associated with dust-PBDE levels. CONCLUSIONS: Our findings suggest that the relative contribution of specific exposure routes to total POP intake varies by chemical class, with dust being a relatively important source of PBDEs and diet being a relatively important source of PCBs.
BACKGROUND:Humans are exposed to persistent organic pollutants (POPs) through various routes, including consumption of contaminated food and accidental ingestion of settled dust. OBJECTIVES: We aimed to identify key routes of exposure to organochlorine pesticides, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) in California women of reproductive age. METHODS: Blood was collected from 48 mothers participating in the California Childhood Leukemia Study from 2006 to 2007 and analyzed for POPs using gas chromatography-mass spectrometry. Multivariable linear regression models of natural-log transformed serum concentrations were used to identify determinants of exposure from available questionnaire information on dietary habits, reproductive history, and demographic characteristics, as well as vacuum cleaner dust-POP levels. RESULTS: After adjusting for blood lipid levels, age, body mass index, cumulative lactation, and sampling date, serum concentrations of multiple major PCBs were positively associated with fish consumption, but not dust-PCB levels. After adjusting for blood lipid levels, Hispanic ethnicity, country of origin, and household annual income, serum concentrations of multiple major PBDEs were positively associated with dust-PBDE levels. CONCLUSIONS: Our findings suggest that the relative contribution of specific exposure routes to total POP intake varies by chemical class, with dust being a relatively important source of PBDEs and diet being a relatively important source of PCBs.
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