Caroline Guyer1, Reto Huber2, Jehudith Fontijn3, Hans Ulrich Bucher3, Heide Nicolai3, Helene Werner4, Luciano Molinari1, Beatrice Latal2, Oskar G Jenni5. 1. Child Development Center, Department of Pediatrics, University Children's Hospital Zürich, CH-8032 Zürich, Switzerland. 2. Child Development Center, Department of Pediatrics, University Children's Hospital Zürich, CH-8032 Zürich, Switzerland; Children's Research Center (CRC), University Children's Hospital Zürich, CH-8032 Zürich, Switzerland. 3. Clinic Neonatology, University Hospital Zürich, CH-8091 Zürich, Switzerland. 4. Child Development Center, Department of Pediatrics, University Children's Hospital Zürich, CH-8032 Zürich, Switzerland; Department of Psychosomatics and Psychiatry, University Children's Hospital Zürich, CH-8032 Zürich, Switzerland. 5. Child Development Center, Department of Pediatrics, University Children's Hospital Zürich, CH-8032 Zürich, Switzerland; Children's Research Center (CRC), University Children's Hospital Zürich, CH-8032 Zürich, Switzerland. Electronic address: Oskar.Jenni@kispi.uzh.ch.
Abstract
BACKGROUND: Previous studies show contradictory results about the emergence of 24-h rhythms and the influence of external time cues on sleep-wake behavior in preterm compared to term infants. AIMS: To examine whether very preterm infants (<32 weeks of gestational age) differ in their emergence of the 24-h sleep-wake rhythm at 5, 11 and 25 weeks corrected age compared to term infants and whether cycled light conditions during neonatal intermediate care affects postnatal 24-h sleep-wake rhythms in preterm infants. STUDY DESIGN: Prospective cohort study with nested interventional trial. SUBJECTS:34 preterm and 14 control term infants were studied. During neonatal hospitalization, preterm infants were randomly assigned to cycled light [7 am-7 pm lights on, 7 pm-7 am lights off, n=17] or dim light condition [lights off whenever the child is asleep, n=17]. OUTCOME MEASURES: Sleep and activity behavior recorded by parental diary and actigraphy at 5, 11 and 25 weeks corrected age. RESULTS: Sleep at nighttime and the longest consolidated sleep period between 12 pm-6 am was longer (mixed model analysis, factor group: p=0.02, resp. p=0.01) and activity at nighttime was lower (p=0.005) at all ages in preterm compared to term infants. Cycled light exposed preterm infants showed the longest nighttime sleep duration. Dim light exposed preterm infants were the least active. CONCLUSIONS:Preterm infants show an earlier emergence of the 24-h sleep-wake rhythm compared to term infants. Thus, the length of exposure to external time cues such as light may be important for the maturation of infant sleep-wake rhythms. Trial registry number: This trial has been registered at www.clinicaltrials.gov (identifier NCT01513226).
RCT Entities:
BACKGROUND: Previous studies show contradictory results about the emergence of 24-h rhythms and the influence of external time cues on sleep-wake behavior in preterm compared to term infants. AIMS: To examine whether very preterm infants (<32 weeks of gestational age) differ in their emergence of the 24-h sleep-wake rhythm at 5, 11 and 25 weeks corrected age compared to term infants and whether cycled light conditions during neonatal intermediate care affects postnatal 24-h sleep-wake rhythms in preterm infants. STUDY DESIGN: Prospective cohort study with nested interventional trial. SUBJECTS: 34 preterm and 14 control term infants were studied. During neonatal hospitalization, preterm infants were randomly assigned to cycled light [7 am-7 pm lights on, 7 pm-7 am lights off, n=17] or dim light condition [lights off whenever the child is asleep, n=17]. OUTCOME MEASURES: Sleep and activity behavior recorded by parental diary and actigraphy at 5, 11 and 25 weeks corrected age. RESULTS: Sleep at nighttime and the longest consolidated sleep period between 12 pm-6 am was longer (mixed model analysis, factor group: p=0.02, resp. p=0.01) and activity at nighttime was lower (p=0.005) at all ages in preterm compared to term infants. Cycled light exposed preterm infants showed the longest nighttime sleep duration. Dim light exposed preterm infants were the least active. CONCLUSIONS: Preterm infants show an earlier emergence of the 24-h sleep-wake rhythm compared to term infants. Thus, the length of exposure to external time cues such as light may be important for the maturation of infantsleep-wake rhythms. Trial registry number: This trial has been registered at www.clinicaltrials.gov (identifier NCT01513226).
Authors: Anneleen Dereymaeker; Kirubin Pillay; Jan Vervisch; Maarten De Vos; Sabine Van Huffel; Katrien Jansen; Gunnar Naulaers Journal: Early Hum Dev Date: 2017-07-12 Impact factor: 2.079
Authors: Debra H Brandon; Susan G Silva; Jinhee Park; William Malcolm; Heba Kamhawy; Diane Holditch-Davis Journal: Res Nurs Health Date: 2017-04-21 Impact factor: 2.228