Zhiyong Shen1, Hua Liu1, Hui Cao2. 1. Department of General Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 200127 Shanghai, China. 2. Department of General Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 200127 Shanghai, China. Electronic address: HuiCaohc@163.com.
Abstract
OBJECTIVES: The aim of this study was to perform an updated review to evaluate the effect of coffee consumption on the risk of gastric cancer. METHODS: We searched the PubMed and Embase database up to October 14th, 2013. Risk ratio (RR) and corresponding 95% confidence intervals (CIs) for the risk of gastric cancer were used as effect sizes. Overall effect sizes were derived using a fixed-effects model or a random-effects model when appropriate. Then in subgroup analyses, the data were reanalyzed, which were stratified by gender, area and follow-up time. RESULTS: A total of 8 separate studies, including 312,993 volunteers (among them 1429 were diagnosed with gastric cancer in 10-18 years' follow-up), were considered in the meta-analysis. The overall estimate of coffee consumption on the risk of gastric cancer showed a pooled RR of 1.24 (95% CI: 1.03-1.49; P=0.026). In subgroup analyses, the pooled RR of gastric cancer was 1.36 (95% CI: 1.06-1.75) for USA volunteers and 1.29 (95% CI: 1.05-1.59) for people with more than 15-year follow-up time. The sensitivity analysis proved the stability and credibility of our results, and there was no significant bias (Begg's test P=0.640, Egger's test P=0.600) among the studies. CONCLUSIONS: It indicated that coffee consumption was associated with the development of gastric cancer. More coffee drinking could result in the increased risk of gastric cancer.
OBJECTIVES: The aim of this study was to perform an updated review to evaluate the effect of coffee consumption on the risk of gastric cancer. METHODS: We searched the PubMed and Embase database up to October 14th, 2013. Risk ratio (RR) and corresponding 95% confidence intervals (CIs) for the risk of gastric cancer were used as effect sizes. Overall effect sizes were derived using a fixed-effects model or a random-effects model when appropriate. Then in subgroup analyses, the data were reanalyzed, which were stratified by gender, area and follow-up time. RESULTS: A total of 8 separate studies, including 312,993 volunteers (among them 1429 were diagnosed with gastric cancer in 10-18 years' follow-up), were considered in the meta-analysis. The overall estimate of coffee consumption on the risk of gastric cancer showed a pooled RR of 1.24 (95% CI: 1.03-1.49; P=0.026). In subgroup analyses, the pooled RR of gastric cancer was 1.36 (95% CI: 1.06-1.75) for USA volunteers and 1.29 (95% CI: 1.05-1.59) for people with more than 15-year follow-up time. The sensitivity analysis proved the stability and credibility of our results, and there was no significant bias (Begg's test P=0.640, Egger's test P=0.600) among the studies. CONCLUSIONS: It indicated that coffee consumption was associated with the development of gastric cancer. More coffee drinking could result in the increased risk of gastric cancer.
Authors: Georgia Martimianaki; Paola Bertuccio; Gianfranco Alicandro; Claudio Pelucchi; Francesca Bravi; Greta Carioli; Rossella Bonzi; Charles S Rabkin; Linda M Liao; Rashmi Sinha; Ken Johnson; Jinfu Hu; Domenico Palli; Monica Ferraroni; Nuno Lunet; Samantha Morais; Shoichiro Tsugane; Akihisa Hidaka; Gerson Shigueaki Hamada; Lizbeth López-Carrillo; Raúl Ulises Hernández-Ramírez; David Zaridze; Dmitry Maximovitch; Nuria Aragonés; Vicente Martin; Mary H Ward; Jesus Vioque; Manoli Garcia de la Hera; Zuo-Feng Zhang; Robert C Kurtz; Pagona Lagiou; Areti Lagiou; Antonia Trichopoulou; Anna Karakatsani; Reza Malekzadeh; M Constanza Camargo; Maria Paula Curado; Stefania Boccia; Paolo Boffetta; Eva Negri; Carlo La Vecchia Journal: Eur J Cancer Prev Date: 2022-03-01 Impact factor: 2.164