Literature DB >> 25458625

A systematic review of the effectiveness of intravenous tranexamic acid administration in managing perioperative blood loss in patients undergoing spine surgery.

Jennifer Badeaux, Diane Hawley.   

Abstract

This systematic review aimed to identify the effectiveness of intravenous tranexamic acid (TXA) administration in managing perioperative blood loss in patients undergoing spine surgery. The study design was a systematic review and meta-analysis. Quantitative articles were pooled in a statistical meta-analysis using the Joanna Briggs Institute Meta-Analysis of Statistical Assessment and Review Instrument. Twelve studies totaling 934 participants carried out between 1960 and 2013 were included in the review. Intraoperative blood loss showed statistically significant (P < .0001) blood loss in the control group compared with that in the treatment group. Perioperative blood loss was approaching significance for blood loss in the control group with an overall P = .067. TXA helps reduce perioperative blood loss for patients undergoing spine surgery. TXA should be administered to patients undergoing spine surgery when significant blood loss is anticipated.
Copyright © 2014 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  blood loss; intraoperative blood loss; perioperative blood loss; postoperative blood loss; spine surgery or diskectomy or laminectomy or spinal fusion; surgical blood loss; tranexamic acid or tranexamic

Mesh：

Substances：

Year:  2014        PMID： 25458625     DOI： 10.1016/j.jopan.2014.06.003

Source DB:  PubMed          Journal:  J Perianesth Nurs        ISSN： 1089-9472            Impact factor:   1.084


  8 in total

1.  Which Route of Tranexamic Acid Administration is More Effective to Reduce Blood Loss Following Total Knee Arthroplasty?

Authors:  Sohrab Keyhani; Ali Akbar Esmailiejah; Mohammad Reza Abbasian; Farshad Safdari
Journal:  Arch Bone Jt Surg       Date:  2016-01

2.  Routine perioperative practices and postoperative outcomes for elective lumbar laminectomies.

Authors:  Mina Tohidi; Tiffany Lung; David Yen
Journal:  J Spine Surg       Date:  2018-09

3.  Effect of Local Tranexamic Acid on the Quality of Bone Healing in a Rat Spinal Fusion Model.

Authors:  Ertugrul Sahin; Haluk Berk; Sermin Ozkal; Pembe Keskinoglu; Pinar Balci; Ali Balci
Journal:  Spine Surg Relat Res       Date:  2021-10-11

4.  Intra-articular versus Intravenous Tranexamic Acid in Total Knee Arthroplasty: A Randomized Clinical Trial.

Authors:  Sm Javad Mortazavi; Babak Sattartabar; Alireza Moharrami; Seyed Hadi Kalantar
Journal:  Arch Bone Jt Surg       Date:  2020-05

Review 5.  Systemic and Topical Use of Tranexamic Acid in Spinal Surgery: A Systematic Review.

Authors:  Sebastian F Winter; Carlo Santaguida; Jean Wong; Michael G Fehlings
Journal:  Global Spine J       Date:  2015-09-21

6.  A Randomized Controlled Trial of Topical Application of Tranexamic Acid in Patients with Thoracolumbar Spine Trauma Undergoing Long-Segment Instrumented Posterior Spinal Fusion.

Authors:  Weera Sudprasert; Terdpong Tanaviriyachai; Kongtush Choovongkomol; Sarut Jongkittanakul; Urawit Piyapromdee
Journal:  Asian Spine J       Date:  2018-10-24

7.  Tranexamic acid reduces blood loss in intertrochanteric fractures: A meta-analysis from randomized controlled trials.

Authors:  Weidong Wang; Jincong Yu
Journal:  Medicine (Baltimore)       Date:  2017-12       Impact factor: 1.889

8.  Castigating intraoperative bleeding: Tranexamic acid, a new ally.

Authors:  Krashan Hanada; Alhasan Ahmad; Hammadeen Shadi; Alnajada Wajdi; Saraireh Haitham; Khresat Wesam; Arabiyat Lamees; Malabeh Qamar; Alqroom Rami
Journal:  Asian J Neurosurg       Date:  2021-03-20
  8 in total

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