Audrey Yondjeu Nouya1, Jobert Richie N Nansseu2, Vicky Joceline Ama Moor3, Constant Anatole Pieme4, Jean Jacques N Noubiap5, Corinne M Tchoula6, Bruno M Mokette7, Ruth Danielle M Takam8, Francine Tankeu9, Jeanne Yonkeu Ngogang10, Andre Pascal Kengne11. 1. University of Mountains, Bangangte, Cameroon. Electronic address: audreynouya@yahoo.fr. 2. Sickle Cell Unit, Mother and Child Centre, Chantal Biya Foundation, Yaounde, Cameroon; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon. Electronic address: jobertrichie_nansseu@yahoo.fr. 3. Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon; Laboratory of Biochemistry, Yaounde University Teaching Hospital, Yaounde, Cameroon. Electronic address: movicky@yahoo.fr. 4. Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon. Electronic address: conanpieme@gmail.com. 5. Internal Medicine Unit, Edea Regional Hospital, Edea, Cameroon. Electronic address: noubiapjj@yahoo.fr. 6. Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon. Electronic address: tchoulacorinne@yahoo.fr. 7. Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon. 8. University of Mountains, Bangangte, Cameroon. Electronic address: truthdan@yahoo.fr. 9. Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon. Electronic address: yerema2003@yahoo.fr. 10. Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon; Laboratory of Biochemistry, Yaounde University Teaching Hospital, Yaounde, Cameroon. Electronic address: jngogang@yahoo.fr. 11. Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon; South African Medical Research Council and University of Cape Town, Cape Town, South Africa. Electronic address: apkengne@yahoo.com.
Abstract
BACKGROUND AND PURPOSE: Fructosamine provides an estimate of diabetes control over a shorter period than HbA1c, and has been proposed as a suitable parameter to monitor glycemic control in low-income countries. The aim of this study was to investigate determinants of fructosamine levels in an urban non-diabetic population of Cameroon. METHODS: This was a cross-sectional study including 437 healthy adults with no known history of diabetes mellitus, aged 40 years and above, recruited from the ten administrative regions, representing major ethnic groups in the country. Plasma glucose and fructosamine were measured after an overnight fasting. Univariable and multivariable analyses were used to investigate the factors associated with fructosamine measurements. RESULTS: Fructosamine levels ranged from 68.2 to 940.8 μmol/l with a mean (standard deviation) of 294.4 (131.3) μmol/l. These levels varied significantly across regions and were higher in men than in women (p=0.001) and in those with screen-detected diabetes than in those with normoglycemia (p<0.0001). There was a negative correlation between fructosamine and body mass index (r=-0.15, p=0.009), and a positive correlation with fasting plasma glucose (FPG) (r=0.37, p<0.0001) and total bilirubinemia (r=0.21, p<0.0001). In multivariable model, sex, BMI, FPG, total bilirubine and screen-detected diabetes were no longer associated with fructosamine levels. CONCLUSION: Fructosamine was not independently associated with age, sex, ethnicity, and the glycemic status. Further studies need to be carried out to better elucidate all the factors determining the measurement of fructosamine in order to accurately interpret its values in diabetic populations.
BACKGROUND AND PURPOSE:Fructosamine provides an estimate of diabetes control over a shorter period than HbA1c, and has been proposed as a suitable parameter to monitor glycemic control in low-income countries. The aim of this study was to investigate determinants of fructosamine levels in an urban non-diabetic population of Cameroon. METHODS: This was a cross-sectional study including 437 healthy adults with no known history of diabetes mellitus, aged 40 years and above, recruited from the ten administrative regions, representing major ethnic groups in the country. Plasma glucose and fructosamine were measured after an overnight fasting. Univariable and multivariable analyses were used to investigate the factors associated with fructosamine measurements. RESULTS:Fructosamine levels ranged from 68.2 to 940.8 μmol/l with a mean (standard deviation) of 294.4 (131.3) μmol/l. These levels varied significantly across regions and were higher in men than in women (p=0.001) and in those with screen-detected diabetes than in those with normoglycemia (p<0.0001). There was a negative correlation between fructosamine and body mass index (r=-0.15, p=0.009), and a positive correlation with fasting plasma glucose (FPG) (r=0.37, p<0.0001) and total bilirubinemia (r=0.21, p<0.0001). In multivariable model, sex, BMI, FPG, total bilirubine and screen-detected diabetes were no longer associated with fructosamine levels. CONCLUSION:Fructosamine was not independently associated with age, sex, ethnicity, and the glycemic status. Further studies need to be carried out to better elucidate all the factors determining the measurement of fructosamine in order to accurately interpret its values in diabetic populations.
Authors: Elizabeth Selvin; Andreea M Rawlings; Pamela L Lutsey; Nisa Maruthur; James S Pankow; Michael Steffes; Josef Coresh Journal: Circulation Date: 2015-05-28 Impact factor: 29.690
Authors: Fernando Riveros-Mckay; David Roberts; Emanuele Di Angelantonio; Bing Yu; Nicole Soranzo; John Danesh; Elizabeth Selvin; Adam S Butterworth; Inês Barroso Journal: Diabetes Date: 2022-02-01 Impact factor: 9.461