| Literature DB >> 25457829 |
A Almangush1, R D Coletta2, I O Bello3, C Bitu4, H Keski-Säntti5, L K Mäkinen5, J H Kauppila6, M Pukkila7, J Hagström8, J Laranne9, S Tommola10, Y Soini11, V-M Kosma11, P Koivunen12, L P Kowalski13, P Nieminen14, R Grénman15, I Leivo16, T Salo17.
Abstract
The prognostication of patient outcome is one of the greatest challenges in the management of early stage oral tongue squamous cell carcinoma (OTSCC). This study introduces a simple histopathological model for the prognostication of survival in patients with early OTSCC. A total of 311 cases (from Finland and Brazil) with clinically evaluated early stage OTSCC (cT1-T2cN0cM0) were included in this multicentre retrospective study. Tumour budding (B) and depth of invasion (D) were scored on haematoxylin-eosin-stained cancer slides. The cut-off point for tumour budding was set at 5 buds (low <5; high ≥5) and for depth of invasion at 4mm (low <4mm; high ≥4mm). The scores of B and D were combined into one model: the BD predictive model. On multivariate analysis, a high risk score (BD score 2) correlated significantly with loco-regional recurrence (P=0.033) and death due to OTSCC (P<0.001) in early stage OTSCC. The new BD model is a promising prognostic tool to identify those patients with aggressive cases of early stage OTSCC who might benefit from multimodality treatment.Entities:
Keywords: BD model; depth of invasion; oral tongue squamous cell carcinoma; prognosis; tumour budding
Mesh：
Year: 2014 PMID： 25457829 DOI： 10.1016/j.ijom.2014.10.004
Source DB: PubMed Journal: Int J Oral Maxillofac Surg ISSN： 0901-5027 Impact factor: 2.789