Literature DB >> 25457350

Disrupting the scaffold, an alternative approach to inhibiting FAK.

Song Chen1, Michael Haas, Shaogang Sun.   

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Year:  2014        PMID： 25457350      PMCID： PMC4613838          DOI： 10.4161/15384101.2014.986629

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


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  7 in total

1.  Distinct FAK activities determine progenitor and mammary stem cell characteristics.

Authors:  Ming Luo; Xiaofeng Zhao; Song Chen; Suling Liu; Max S Wicha; Jun-Lin Guan
Journal:  Cancer Res       Date:  2013-07-05       Impact factor: 12.701

2.  A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells.

Authors:  Elena Kurenova; Deniz Ucar; Jianqun Liao; Michael Yemma; Priyanka Gogate; Wiam Bshara; Ulas Sunar; Mukund Seshadri; Steven N Hochwald; William G Cance
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

3.  Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo.

Authors:  Huaping Fan; Xiaofeng Zhao; Shaogang Sun; Ming Luo; Jun-Lin Guan
Journal:  J Biol Chem       Date:  2012-12-19       Impact factor: 5.157

4.  Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.

Authors:  Vita M Golubovskaya; Grace Huang; Baotran Ho; Michael Yemma; Carl D Morrison; Jisook Lee; Brian P Eliceiri; William G Cance
Journal:  Mol Cancer Ther       Date:  2012-12-12       Impact factor: 6.261

5.  Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development.

Authors:  Xiaofeng Zhao; Xu Peng; Shaogang Sun; Ann Y J Park; Jun-Lin Guan
Journal:  J Cell Biol       Date:  2010-06-07       Impact factor: 10.539

6.  Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.

Authors:  Elena V Kurenova; Darell L Hunt; Dihua He; Andrew T Magis; David A Ostrov; William G Cance
Journal:  J Med Chem       Date:  2009-08-13       Impact factor: 7.446

7.  Endothelial FAK is required for tumour angiogenesis.

Authors:  Bernardo Tavora; Silvia Batista; Louise E Reynolds; Shalini Jadeja; Stephen Robinson; Vassiliki Kostourou; Ian Hart; Marcus Fruttiger; Maddy Parsons; Kairbaan M Hodivala-Dilke
Journal:  EMBO Mol Med       Date:  2010-12       Impact factor: 12.137
  7 in total

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