Literature DB >> 25457120

Chemical cryptology of cancer's histone code.

Rhushikesh A Kulkarni1, Jordan L Meier2.   

Abstract

Somatic mutations in non-Hodgkin's lymphoma frequently activate EZH2, a protein methyltransferase responsible for H3K27 trimethylation. In this issue of Chemistry and Biology, Bradley and coworkers describe a new set of EZH2 inhibitors amenable to probing the targetable role of H3K27 trimethylation in lymphoma.
Copyright © 2014 Elsevier Ltd. All rights reserved.

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Year:  2014        PMID： 25457120      PMCID： PMC6320250          DOI： 10.1016/j.chembiol.2014.11.003

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  12 in total

1.  Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

Authors:  Daniel Martinez Molina; Rozbeh Jafari; Marina Ignatushchenko; Takahiro Seki; E Andreas Larsson; Chen Dan; Lekshmy Sreekumar; Yihai Cao; Pär Nordlund
Journal:  Science       Date:  2013-07-05       Impact factor: 47.728

Review 2.  Transcriptional regulation by Polycomb group proteins.

Authors:  Luciano Di Croce; Kristian Helin
Journal:  Nat Struct Mol Biol       Date:  2013-10       Impact factor: 15.369

3.  Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest.

Authors:  Isabel Hidalgo; Antonio Herrera-Merchan; Jose Manuel Ligos; Laura Carramolino; Javier Nuñez; Fernando Martinez; Orlando Dominguez; Miguel Torres; Susana Gonzalez
Journal:  Cell Stem Cell       Date:  2012-11-02       Impact factor: 24.633

4.  Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide.

Authors:  Eva Madi Riising; Itys Comet; Benjamin Leblanc; Xudong Wu; Jens Vilstrup Johansen; Kristian Helin
Journal:  Mol Cell       Date:  2014-07-03       Impact factor: 17.970

Review 5.  Epigenetics and B-cell lymphoma.

Authors:  Rita Shaknovich; Ari Melnick
Journal:  Curr Opin Hematol       Date:  2011-07       Impact factor: 3.284

6.  EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.

Authors:  Michael T McCabe; Heidi M Ott; Gopinath Ganji; Susan Korenchuk; Christine Thompson; Glenn S Van Aller; Yan Liu; Alan P Graves; Anthony Della Pietra; Elsie Diaz; Louis V LaFrance; Mark Mellinger; Celine Duquenne; Xinrong Tian; Ryan G Kruger; Charles F McHugh; Martin Brandt; William H Miller; Dashyant Dhanak; Sharad K Verma; Peter J Tummino; Caretha L Creasy
Journal:  Nature       Date:  2012-10-10       Impact factor: 49.962

7.  A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.

Authors:  Sarah K Knutson; Tim J Wigle; Natalie M Warholic; Christopher J Sneeringer; Christina J Allain; Christine R Klaus; Joelle D Sacks; Alejandra Raimondi; Christina R Majer; Jeffrey Song; Margaret Porter Scott; Lei Jin; Jesse J Smith; Edward J Olhava; Richard Chesworth; Mikel P Moyer; Victoria M Richon; Robert A Copeland; Heike Keilhack; Roy M Pollock; Kevin W Kuntz
Journal:  Nat Chem Biol       Date:  2012-09-30       Impact factor: 15.040

8.  Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation.

Authors:  Wei Qi; HoMan Chan; Lin Teng; Ling Li; Shannon Chuai; Ruipeng Zhang; Jue Zeng; Min Li; Hong Fan; Ying Lin; Justin Gu; Ophelia Ardayfio; Ji-Hu Zhang; Xiaoxia Yan; Jialuo Fang; Yuan Mi; Man Zhang; Tao Zhou; Grace Feng; Zijun Chen; Guobin Li; Teddy Yang; Kehao Zhao; Xianghui Liu; Zhengtian Yu; Chris X Lu; Peter Atadja; En Li
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-10       Impact factor: 11.205

9.  Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.

Authors:  Sarah K Knutson; Natalie M Warholic; Tim J Wigle; Christine R Klaus; Christina J Allain; Alejandra Raimondi; Margaret Porter Scott; Richard Chesworth; Mikel P Moyer; Robert A Copeland; Victoria M Richon; Roy M Pollock; Kevin W Kuntz; Heike Keilhack
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-25       Impact factor: 11.205

10.  Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth.

Authors:  Shivani Garapaty-Rao; Christopher Nasveschuk; Alexandre Gagnon; Eric Y Chan; Peter Sandy; Jennifer Busby; Srividya Balasubramanian; Robert Campbell; Feng Zhao; Louise Bergeron; James E Audia; Brian K Albrecht; Jean-Christophe Harmange; Richard Cummings; Patrick Trojer
Journal:  Chem Biol       Date:  2013-10-31
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