Ghazaleh Eslamian1, Naser Amirjannati2, Bahram Rashidkhani3, Mohammad-Reza Sadeghi2, Ahmad-Reza Baghestani4, Azita Hekmatdoost5. 1. Students' Research Committee, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Department of Andrology and Embryology, Reproductive Biotechnology Research Center, Avicenna Research Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran. 3. Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: a_hekmat2000@yahoo.com.
Abstract
OBJECTIVE: To investigate the association between dietary fatty acids intakes and asthenozoospermia. DESIGN: Case-control study. SETTING: Infertility clinics. PATIENT(S): A total of 107 men with incident asthenozoospermia and 235 age-matched controls. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Assessments of dietary intakes, semen quality, anthropometry, endocrine parameters, and demographic information. RESULT(S): According to the fully adjusted model, being in the highest tertile of total saturated fatty acids (odds ratio [OR] = 1.85, 95% confidence interval [CI] 1.24-2.96), total trans-fatty acids (OR = 2.53, 95% CI 1.54-3.92), palmitic acid (OR = 1.90, 95% CI 1.26-2.74), and stearic acid (OR = 2.13, 95% CI 1.29-3.88) was positively associated with asthenozoospermia. Whereas higher intakes of omega-3 polyunsaturated (OR = 0.68, 95% CI 0.58-0.94) and of docosahexaenoic (OR = 0.53, 95% CI 0.29-0.89) fatty acids were significantly associated with reduced odds of asthenozoospermia. CONCLUSION(S): Our findings suggest that the high intake of saturated and trans-fats was positively related to the odds of having asthenozoospermia. Conversely, inverse and dose-dependent associations were found between asthenozoospermia and intake of omega-3 polyunsaturated fatty acids. The observed associations of different types of fatty acids underline the importance of the type of fat in the etiology of asthenozoospermia.
OBJECTIVE: To investigate the association between dietary fatty acids intakes and asthenozoospermia. DESIGN: Case-control study. SETTING: Infertility clinics. PATIENT(S): A total of 107 men with incident asthenozoospermia and 235 age-matched controls. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Assessments of dietary intakes, semen quality, anthropometry, endocrine parameters, and demographic information. RESULT(S): According to the fully adjusted model, being in the highest tertile of total saturated fatty acids (odds ratio [OR] = 1.85, 95% confidence interval [CI] 1.24-2.96), total trans-fatty acids (OR = 2.53, 95% CI 1.54-3.92), palmitic acid (OR = 1.90, 95% CI 1.26-2.74), and stearic acid (OR = 2.13, 95% CI 1.29-3.88) was positively associated with asthenozoospermia. Whereas higher intakes of omega-3 polyunsaturated (OR = 0.68, 95% CI 0.58-0.94) and of docosahexaenoic (OR = 0.53, 95% CI 0.29-0.89) fatty acids were significantly associated with reduced odds of asthenozoospermia. CONCLUSION(S): Our findings suggest that the high intake of saturated and trans-fats was positively related to the odds of having asthenozoospermia. Conversely, inverse and dose-dependent associations were found between asthenozoospermia and intake of omega-3 polyunsaturated fatty acids. The observed associations of different types of fatty acids underline the importance of the type of fat in the etiology of asthenozoospermia.
Authors: Lauren A Wise; Amelia K Wesselink; Katherine L Tucker; Shilpa Saklani; Ellen M Mikkelsen; Heidi Cueto; Anders H Riis; Ellen Trolle; Craig J McKinnon; Kristen A Hahn; Kenneth J Rothman; Henrik Toft Sørensen; Elizabeth E Hatch Journal: Am J Epidemiol Date: 2018-01-01 Impact factor: 4.897
Authors: Lauren A Wise; Sydney K Willis; Ellen M Mikkelsen; Amelia K Wesselink; Henrik Toft Sørensen; Kenneth J Rothman; Katherine L Tucker; Ellen Trolle; Marco Vinceti; Elizabeth E Hatch Journal: Nutrients Date: 2020-07-29 Impact factor: 5.717