Jose V Bagan1, Felix Carbonell2, Maria J Gómez3, Magdalena Sánchez4, Atilio Navarro5, Manuel Leopoldo6, Leticia Bagán7, Enrique Zapater3. 1. Department of Oral Medicine, Valencia University, Valencia, Spain; Department of Oral and Maxillofacial Surgery, University General Hospital, Valencia, Spain. Electronic address: bagan@uv.es. 2. Department of Hematology, Valencia University, Valencia, Spain; Department of Hematology, University General Hospital, Valencia, Spain. 3. ENT Unit, University General Hospital, Valencia, Spain. 4. Department of Hematology, University General Hospital, Valencia, Spain. 5. Department of Pathology, University General Hospital, Valencia, Spain. 6. Department of Oral and Maxillofacial Surgery, University General Hospital, Valencia, Spain. 7. Department of Oral Medicine, Valencia University, Valencia, Spain.
Abstract
OBJECTIVES: The objectives of this study are to describe the distinctive characteristics of extra-nodal B-cell non-Hodgkin's lymphomas (BNHLs) located in the head and neck in a series of patients, to discuss patient survival, and to compare the oral versus the non-oral locations of the extra-nodal BNHLs of the head and neck. MATERIAL AND METHODS: We studied 68 patients with BNHL of the head and neck. We analyzed the clinical and survival characteristics. Additionally, we performed Kaplan-Meier and Cox regression analyses to determine the influence of the different factors on survival. RESULTS: This study included 68 non-nodal lymphomas; 30 lymphomas (31.9%) were located intraorally, with the gingiva as the most frequent location. The oral lymphomas in stages 1 and 2 showed a prevalence of 60% (18/30). The Kaplan-Meier analysis showed that the stage of disease and the oral versus non-oral extranodal lymphomas were significant prognostic factors (p<0.05). However, the multivariate Cox analysis indicated that only complete remission and oral versus non-oral location were significant prognostic factors (p<0.01). CONCLUSIONS: The gingiva was the most common location of the intraoral lymphomas. Complete remission and non-oral location were the only significant survival factors in the multivariate Cox regression analysis.
OBJECTIVES: The objectives of this study are to describe the distinctive characteristics of extra-nodal B-cell non-Hodgkin's lymphomas (BNHLs) located in the head and neck in a series of patients, to discuss patient survival, and to compare the oral versus the non-oral locations of the extra-nodal BNHLs of the head and neck. MATERIAL AND METHODS: We studied 68 patients with BNHL of the head and neck. We analyzed the clinical and survival characteristics. Additionally, we performed Kaplan-Meier and Cox regression analyses to determine the influence of the different factors on survival. RESULTS: This study included 68 non-nodal lymphomas; 30 lymphomas (31.9%) were located intraorally, with the gingiva as the most frequent location. The oral lymphomas in stages 1 and 2 showed a prevalence of 60% (18/30). The Kaplan-Meier analysis showed that the stage of disease and the oral versus non-oral extranodal lymphomas were significant prognostic factors (p<0.05). However, the multivariate Cox analysis indicated that only complete remission and oral versus non-oral location were significant prognostic factors (p<0.01). CONCLUSIONS: The gingiva was the most common location of the intraoral lymphomas. Complete remission and non-oral location were the only significant survival factors in the multivariate Cox regression analysis.
Authors: Alba Bello Castro; Juan Seoane; Máximo Francisco Fraga Rodríguez; Francisco Gude Sampedro; Javier Seoane Romero; Benjamín Martin-Biedma; Pablo Castelo-Baz Journal: J Clin Med Date: 2022-02-06 Impact factor: 4.241