Literature DB >> 2545647

Oxidative inhibition of Ca2+-ATPase in the rabbit lens.

D Borchman1, C A Paterson, N A Delamere.   

Abstract

Hydrogen peroxide inhibition of maximum Ca2+-ATPase and Na+,K+-ATPase activity was measured in a membrane-enriched preparation of rabbit lens cortical fibers and epithelium. At 5 X 10(-6) M hydrogen peroxide maximum Ca2+-ATPase activity was inhibited by 39%, while maximum Na+,K+-ATPase activity was stimulated. Ca2+-ATPase activity was almost completely inhibited at 5 X 10(-4) M hydrogen peroxide, in comparison to Na+,K+-ATPase activity, which was only inhibited by 28% at a concentration of hydrogen peroxide an order of magnitude larger. The addition of catalase to hydrogen peroxide-pretreated samples did not reverse the inhibition of Ca2+-ATPase by hydrogen peroxide.

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Year:  1989        PMID： 2545647

Source DB:  PubMed          Journal:  Invest Ophthalmol Vis Sci        ISSN： 0146-0404            Impact factor:   4.799


  9 in total

1.  Effect of verapamil on lenticular calcium, magnesium and iron in radiation exposed rats.

Authors:  Y Bardak; O Cekiç; Y Totan; M Cengiz
Journal:  Int Ophthalmol       Date:  1998       Impact factor: 2.031

Review 2.  Identification and functional clustering of global gene expression differences between age-related cataract and clear human lenses and aged human lenses.

Authors:  J R Hawse; J F Hejtmancik; J Horwitz; M Kantorow
Journal:  Exp Eye Res       Date:  2004-12       Impact factor: 3.467

3.  Identification and functional clustering of global gene expression differences between human age-related cataract and clear lenses.

Authors:  John R Hawse; James F Hejtmancik; Quingling Huang; Nancy L Sheets; Douglas A Hosack; Richard A Lempicki; Joseph Horwitz; Marc Kantorow
Journal:  Mol Vis       Date:  2003-10-07       Impact factor: 2.367

4.  Deciphering the potential efficacy of acetyl-L-carnitine (ALCAR) in maintaining connexin-mediated lenticular homeostasis.

Authors:  Arumugam Ramachandran Muralidharan; George Leema; Thangaraj Annadurai; Thirugnanasambandhar Sivasubramanian Anitha; Philip A Thomas; Pitchairaj Geraldine
Journal:  Mol Vis       Date:  2012-07-25       Impact factor: 2.367

5.  Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors.

Authors:  E M McElnea; B Quill; N G Docherty; M Irnaten; W F Siah; A F Clark; C J O'Brien; D M Wallace
Journal:  Mol Vis       Date:  2011-05-05       Impact factor: 2.367

6.  Regulatory effect of chrysin on expression of lenticular calcium transporters, calpains, and apoptotic-cascade components in selenite-induced cataract.

Authors:  Mahalingam Sundararajan; Philip A Thomas; P Archana Teresa; Muniyandi Anbukkarasi; Pitchairaj Geraldine
Journal:  Mol Vis       Date:  2016-04-30       Impact factor: 2.367

7.  Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats.

Authors:  Nurul Alimah Abdul Nasir; Renu Agarwal; Siti Hamimah Sheikh Abdul Kadir; Sushil Vasudevan; Minaketan Tripathy; Igor Iezhitsa; Aqil Mohammad Daher; Mohd Ikraam Ibrahim; Nafeeza Mohd Ismail
Journal:  PLoS One       Date:  2017-03-28       Impact factor: 3.240

8.  The effect of hydrogen peroxide on sarco/endoplasmic and plasma membrane calcium ATPase gene expression in cultured human lens epithelial cells.

Authors:  M J Marian; P Mukhopadhyay; D Borchman; D Tang; C A Paterson
Journal:  Open Ophthalmol J       Date:  2008-07-07

9.  Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals.

Authors:  W C Li; J R Kuszak; K Dunn; R R Wang; W Ma; G M Wang; A Spector; M Leib; A M Cotliar; M Weiss
Journal:  J Cell Biol       Date:  1995-07       Impact factor: 10.539
  9 in total

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