Dae-Myung Park1, Seok-Hwan Kim1, Yang-Chun Park2, Wee-Chang Kang3, Sang-Ryong Lee1, In-Chul Jung4. 1. Department of Psychiatry, Oriental Medical College of Daejeon University, 96-3 Yongwun-dong, Daejeon 300-716, Republic of Korea. 2. Department of Internal Medicine, Oriental Medical College of Daejeon University, 96-3 Yongwun-dong, Daejeon 300-716, Republic of Korea. 3. Department of Business Information Statistics, College of Business Ministration, Daejeon University, 96-3 Yongwun-dong, Daejeon 300-716, Republic of Korea. 4. Department of Psychiatry, Oriental Medical College of Daejeon University, 96-3 Yongwun-dong, Daejeon 300-716, Republic of Korea. Electronic address: npjeong@dju.kr.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Gamisoyo-San (GSS) is a well-known Traditional Korean Medicine shown to be effective on mood disorders. AIM OF THE STUDY: The purpose of this research is to examine the effect of Gamisoyo-San on generalized anxiety disorder by its differently manufactured preparations. MATERIALS AND METHODS: Multicenter, randomized, double-blinded, placebo-controlled study was set for 147 patients with generalized anxiety disorder recruited from November 1st 2009 to December 16th 2010. They were given Gamisoyo-San individual extract mixture (extraction done for each crude materia medica separately) or Gamisoyo-San multi-compound extract (extraction done for whole materia medica at once) or controlled medication. Hamilton Rating Scale for Anxiety (HAM-A), Korean State-Trait Anxiety Inventory (K-STAI), Penn State Worry Questionnaire (PSWQ), Korean Beck Depression Inventroy (K-BDI), Symptom Checklist-90-Revised (SCL-90-R), and Korean WHO Quality of Life Scale Abbreviated Version (WHOQOL-BREF) were evaluated. We also applied Pattern Identification tool for 'JingJi and ZhengChong (, Traditional Korean Medicine term which correlates with generalized anxiety disorder)' to patients to evaluate different responses among 9 patterns. RESULTS: HAM-A scores of Gamisoyo-San multi-compound extract group showed greater decrease compared to Gamisoyo-San individual extract mixture group and placebo group, but the difference was insignificant. WHOQOL-BREF scores of Gamisoyo-San multi-compound extract group showed significant increase compared to Gamisoyo-San individual extract mixture group and placebo group. In Heart blood deficiency pattern, the Gamisoyo-San multi-compound extract group showed significant decrease in K-BDI compared to the Gamisoyo-San individual extract mixture group. CONCLUSION:Gamisoyo-San did not improve anxiety level of GAD patients. However, it can be useful to improve quality of life, and reduce depressive, obsessive-compulsive, somatic symptoms of generalized anxiety disorder. Gamisoyo-San multi-compound seemed more effective than Gamisoyo-San individual extract mixture, especially in Heart blood deficiency pattern.
RCT Entities:
ETHNOPHARMACOLOGICAL RELEVANCE: Gamisoyo-San (GSS) is a well-known Traditional Korean Medicine shown to be effective on mood disorders. AIM OF THE STUDY: The purpose of this research is to examine the effect of Gamisoyo-San on generalized anxiety disorder by its differently manufactured preparations. MATERIALS AND METHODS: Multicenter, randomized, double-blinded, placebo-controlled study was set for 147 patients with generalized anxiety disorder recruited from November 1st 2009 to December 16th 2010. They were given Gamisoyo-San individual extract mixture (extraction done for each crude materia medica separately) or Gamisoyo-San multi-compound extract (extraction done for whole materia medica at once) or controlled medication. Hamilton Rating Scale for Anxiety (HAM-A), Korean State-Trait Anxiety Inventory (K-STAI), Penn State Worry Questionnaire (PSWQ), Korean Beck Depression Inventroy (K-BDI), Symptom Checklist-90-Revised (SCL-90-R), and Korean WHO Quality of Life Scale Abbreviated Version (WHOQOL-BREF) were evaluated. We also applied Pattern Identification tool for 'JingJi and ZhengChong (, Traditional Korean Medicine term which correlates with generalized anxiety disorder)' to patients to evaluate different responses among 9 patterns. RESULTS: HAM-A scores of Gamisoyo-San multi-compound extract group showed greater decrease compared to Gamisoyo-San individual extract mixture group and placebo group, but the difference was insignificant. WHOQOL-BREF scores of Gamisoyo-San multi-compound extract group showed significant increase compared to Gamisoyo-San individual extract mixture group and placebo group. In Heart blood deficiency pattern, the Gamisoyo-San multi-compound extract group showed significant decrease in K-BDI compared to the Gamisoyo-San individual extract mixture group. CONCLUSION:Gamisoyo-San did not improve anxiety level of GAD patients. However, it can be useful to improve quality of life, and reduce depressive, obsessive-compulsive, somatic symptoms of generalized anxiety disorder. Gamisoyo-San multi-compound seemed more effective than Gamisoyo-San individual extract mixture, especially in Heart blood deficiency pattern.
Authors: Emily Carl; Sara M Witcraft; Brooke Y Kauffman; Eilis M Gillespie; Eni S Becker; Pim Cuijpers; Michael Van Ameringen; Jasper A J Smits; Mark B Powers Journal: Cogn Behav Ther Date: 2019-02-14