| Literature DB >> 25456389 |
Qi Chen1, Chong Liu1, Gloria Komazin2, Terry L Bowlin2, Stewart W Schneller3.
Abstract
The naturally occurring adenine based carbocyclic nucleosides aristeromycin and neplanocin A and their 3-deaza analogues have found a prominent place in the search for diverse antiviral activity agent scaffolds because of their ability to inhibit S-adenosylhomocysteine (AdoHcy) hydrolase. Following the lead of these compounds, their 3-deaza-3-fluoroaristeromycin analogues have been synthesized and their effect on S-adenosylhomocysteine hydrolase and RNA and DNA viruses determined.Entities:
Keywords: 3-Deazaaristeromycin; AdoHcy hydrolase; Carbocyclic nucleosides; Measles; Mitsunobu coupling; Monkeypox
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Year: 2014 PMID： 25456389 DOI： 10.1016/j.bmc.2014.10.014
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641