| Literature DB >> 25455487 |
Junwon Kim1, Jeongjin Kwon1, Doohyun Lee1, Suyeon Jo1, Dong-Sik Park1, Jihyun Choi1, Eunjung Park1, Jong Yeon Hwang1, Yoonae Ko1, Inhee Choi1, Moon Kyeong Ju1, JiYe Ahn1, Junghwan Kim1, Sung-Jun Han1, Tae-Hee Kim1, Jonathan Cechetto1, Jiyoun Nam1, Sujin Ahn1, Peter Sommer1, Michel Liuzzi1, Jinhwa Lee1.
Abstract
We identified a novel class of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine compounds as potent HIV-1 replication inhibitors serendipitously during the process of evaluation of triazolothienopyrimidine (TTPM) compounds. Herein, we report synthesis and biological evaluation of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine compounds using a cell-based full replication assay to identify thienopyrimidines 6 and 30, which could be further utilized as viable lead compounds.Entities:
Keywords: Cell-based assay; HIV-1; Inhibitor; Structure–activity relationship; Thienopyrimidine
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Year: 2014 PMID： 25455487 DOI： 10.1016/j.bmcl.2014.10.007
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823