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Literature DB >> 25455202

Lessons from a great developmental biologist.

Abstract

The announcement that Sir John Gurdon had been awarded the 2012 Nobel Prize for Medicine or Physiology was received with great joy by developmental biologists. It was a very special occasion because of his total dedication to science and turning the Golden Rule of western civilization - love your neighbor as yourself - into a reality in our field. This essay attempts to explain how John became such a great scientific benefactor, and to review some of his discoveries that are less well known than the nuclear transplantation experiments. A few personal anecdotes are also included to illustrate the profound goodness of this unique man of science.

Entities: Chemical

Keywords: JB Gurdon; Nuclear reprogramming; Nuclear transplantation; Xenopus

Mesh：

Year: 2014 PMID： 25455202 PMCID： PMC4286343 DOI： 10.1016/j.diff.2013.12.004

Source DB: PubMed Journal: Differentiation ISSN： 0301-4681 Impact factor: 3.880

23 in total

1. The introduction of Xenopus laevis into developmental biology: of empire, pregnancy testing and ribosomal genes.

Authors: J B Gurdon; N Hopwood
Journal: Int J Dev Biol Date: 2000 Impact factor: 2.203

2. ABSENCE OF RIBOSOMAL RNA SYNTHESIS IN THE ANUCLEOLATE MUTANT OF XENOPUS LAEVIS.

Authors: D D BROWN; J B GURDON
Journal: Proc Natl Acad Sci U S A Date: 1964-01 Impact factor: 11.205

3. Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription.

Authors: Ray Kit Ng; J B Gurdon
Journal: Nat Cell Biol Date: 2007-12-09 Impact factor: 28.824

4. A community effect in animal development.

Authors: J B Gurdon
Journal: Nature Date: 1988 Dec 22-29 Impact factor: 49.962

5. Nuclear transplantation and the control of gene activity in animal development.

Authors: J B Gurdon
Journal: Proc R Soc Lond B Biol Sci Date: 1970-12-01

6. Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis.

Authors: P Lemaire; N Garrett; J B Gurdon
Journal: Cell Date: 1995-04-07 Impact factor: 41.582

7. Activation of muscle-specific actin genes in Xenopus development by an induction between animal and vegetal cells of a blastula.

Authors: J B Gurdon; S Fairman; T J Mohun; S Brennan
Journal: Cell Date: 1985-07 Impact factor: 41.582

8. Nuclei of adult mammalian somatic cells are directly reprogrammed to oct-4 stem cell gene expression by amphibian oocytes.

Authors: James A Byrne; Stina Simonsson; Patrick S Western; John B Gurdon
Journal: Curr Biol Date: 2003-07-15 Impact factor: 10.834