| Literature DB >> 2545512 |
M Oshita1, S Kigoshi, I Muramatsu.
Abstract
1. Neuropeptide Y (NPY) potentiated the contractile responses induced by electrical transmural stimulation, noradrenaline and KCl in the rabbit mesenteric artery. 2. In preparations treated with noradrenaline or KCl in Ca2+ free medium, NPY also potentiated the contractile response induced by resupplementation of Ca2+. 3. 3H-efflux from the arteries preincubated with [3H]-noradrenaline was not affected by NPY. 4. These results suggest that NPY selectively acts on the postsynaptic membrane and potentiates the contractions mediated through receptor-operated and voltage-dependent Ca channels.Entities:
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Year: 1989 PMID： 2545512 DOI： 10.1016/0306-3623(89)90274-7
Source DB: PubMed Journal: Gen Pharmacol ISSN： 0306-3623