| Literature DB >> 25454626 |
Renata Sokolik1, Katarzyna Gębura2, Milena Iwaszko2, Jerzy Świerkot1, Lucyna Korman1, Piotr Wiland1, Katarzyna Bogunia-Kubik3.
Abstract
Psoriatic arthritis (PsA) is a complex genetic disorder that results from an interplay between multiple genetic and environmental factors. The aim of the study was to assess the significance of the association between the HLA-C and HLA-E allelic groups and PsA. Our results confirm the association between HLA-C(∗)06 and PsA (OR=5.16, p<0.0001). Furthermore, HLA-C(∗)06-positive patients develop more severe disease (p<0.01) and more frequently present with polyarticular pattern of PsA (p=0.08). Additionally our study revealed that the HLA-C(∗)02 allele was more frequently observed in PsA patients (OR=5.40, p<0.0005) and also that the HLA-E(∗)01:01 allele was significantly over-represented among HLA-C(∗)02-negative patients in comparison to healthy individuals (OR=6.44, p=0.045). Therefore these results suggest that the HLA-E and HLA-C(∗)02 molecules may also play an important role in determination immune response contributing to the PsA development.Entities:
Keywords: Disease phenotype; HLA-C; HLA-E; Polish population (Poles); Psoriatic arthritis
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Year: 2014 PMID： 25454626 DOI： 10.1016/j.humimm.2014.10.005
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850