B Clemens1, S Puskás2, M Besenyei3, N Zs Kovács1, T Spisák4, S A Kis4, M Emri4, K Hollódy5, A Fogarasi6, I Kondákor7, I Fekete8. 1. Kenézy Gyula County Hospital, Department of Neurology, Debrecen, Hungary. 2. University of Debrecen, Medical Center, Department of Neurology, Debrecen, Hungary. Electronic address: szilvia.puskas@yahoo.com. 3. University of Debrecen, Medical Center, Department of Pediatrics, Debrecen, Hungary. 4. University of Debrecen, Department of Nuclear Medicine, Debrecen, Hungary. 5. University of Pécs, Department of Pediatrics, Pécs, Hungary. 6. Epilepsy Center, Bethesda Children's Hospital, Budapest, Hungary. 7. Balassa János Hospital, Department of Neurology, Szekszárd, Hungary. 8. University of Debrecen, Medical Center, Department of Neurology, Debrecen, Hungary.
Abstract
AIM: To investigate the effect of chronic VPA treatment of EEG functional connectivity in successfully treated idiopathic generalized epilepsy (IGE) patients. PATIENTS AND METHODS: 19-channel waking, resting-state EEG records of 26 IGE patients were analyzed before treatment (IGE) and after the 90th day of treatment (VPA), in seizure-free condition. Three minutes of artifact-free EEG background activity (without epileptiform potentials) was analyzed for each patient in both conditions. A group of 26 age-matched healthy normative control persons (NC) was analyzed in the same way. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography) to localize multiple distributed sources of EEG activity. Current source density time series were generated for 33 regions of interest (ROI) in each hemisphere for four frequency bands. Pearson correlation coefficients (R) were computed between all ROIs in each hemisphere, for four bands across the investigated samples. R values corresponded to intrahemispheric, cortico-cortical functional EEG connectivity (EEGfC). Group and condition differences were analyzed by statistical parametric network method. MAIN RESULTS: p<0.05, corrected for multiple comparisons: (1) The untreated IGE group showed increased EEGfC in the delta and theta bands, and decreased EEGfC in the alpha band (as compared to the NC group); (2) VPA treatment normalized EEGfC in the delta, theta and alpha bands; and (3) degree of normalization depended on frequency band and cortical region. CONCLUSIONS: VPA treatment normalizes EEGfC in IGE patients.
AIM: To investigate the effect of chronic VPA treatment of EEG functional connectivity in successfully treated idiopathic generalized epilepsy (IGE) patients. PATIENTS AND METHODS: 19-channel waking, resting-state EEG records of 26 IGE patients were analyzed before treatment (IGE) and after the 90th day of treatment (VPA), in seizure-free condition. Three minutes of artifact-free EEG background activity (without epileptiform potentials) was analyzed for each patient in both conditions. A group of 26 age-matched healthy normative control persons (NC) was analyzed in the same way. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography) to localize multiple distributed sources of EEG activity. Current source density time series were generated for 33 regions of interest (ROI) in each hemisphere for four frequency bands. Pearson correlation coefficients (R) were computed between all ROIs in each hemisphere, for four bands across the investigated samples. R values corresponded to intrahemispheric, cortico-cortical functional EEG connectivity (EEGfC). Group and condition differences were analyzed by statistical parametric network method. MAIN RESULTS: p<0.05, corrected for multiple comparisons: (1) The untreated IGE group showed increased EEGfC in the delta and theta bands, and decreased EEGfC in the alpha band (as compared to the NC group); (2) VPA treatment normalized EEGfC in the delta, theta and alpha bands; and (3) degree of normalization depended on frequency band and cortical region. CONCLUSIONS:VPA treatment normalizes EEGfC in IGE patients.
Authors: Remi Stevelink; Jurjen J Luykx; Bochao D Lin; Costin Leu; Dennis Lal; Alexander W Smith; Dick Schijven; Johannes A Carpay; Koen Rademaker; Roiza A Rodrigues Baldez; Orrin Devinsky; Kees P J Braun; Floor E Jansen; Dirk J A Smit; Bobby P C Koeleman Journal: Epilepsia Date: 2021-05-18 Impact factor: 6.740
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