Xiaofen Ma1, Shumei Li2, Junzhang Tian2, Guihua Jiang3, Hua Wen2, Tianyue Wang1, Jin Fang2, Wenfeng Zhan2, Yikai Xu4. 1. Medical Imaging Centre, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Ave North, Guangzhou 510515, China. 2. Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, No. 1 Shiliugang Road, Haizhu Distinct, Guangzhou 510317, China. 3. Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, No. 1 Shiliugang Road, Haizhu Distinct, Guangzhou 510317, China. Electronic address: GH.jiang2002@163.com. 4. Medical Imaging Centre, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Ave North, Guangzhou 510515, China. Electronic address: yikaivip@163.com.
Abstract
OBJECTIVE: We aimed to provide additional evidence that brain functional alterations induced by IBS are not limited to local changes but also express at a level of functional integration within related brain regions involved in processing of visceral afferent information and somatic pain. METHODS: With fMRI data acquired from 21 IBS and healthy control (HC) subjects. We investigated the amplitude of low-frequency fluctuation (ALFF) and region of interest (ROI)-based functional connectivity (FC) to reveal the changes of the brain spontaneous activity and the interaction among different related regions. RESULTS: IBS patients showed decreased ALFF values in the left superior frontal gyrus, right hippocampus, right middle frontal gyrus, bilateral postcentral, and right superior temporal pole, while increased ALFF values in the left median cingulate and left calcarine. There was significant correlation between ALFF values in the altered regions and duration of disease in IBS. FC analysis revealed the increased connectivity between cingulate and frontal cortex in IBS. CONCLUSIONS: Our findings could provide both regional and brain connectivity spontaneous neuronal activity properties in IBS. SIGNIFICANCE: Our study may lead to a better understanding of intrinsic functional architecture of brain activity in IBS and highlight the potential for using the ALFF and FC metrics as a disease biomarker.
OBJECTIVE: We aimed to provide additional evidence that brain functional alterations induced by IBS are not limited to local changes but also express at a level of functional integration within related brain regions involved in processing of visceral afferent information and somatic pain. METHODS: With fMRI data acquired from 21 IBS and healthy control (HC) subjects. We investigated the amplitude of low-frequency fluctuation (ALFF) and region of interest (ROI)-based functional connectivity (FC) to reveal the changes of the brain spontaneous activity and the interaction among different related regions. RESULTS:IBSpatients showed decreased ALFF values in the left superior frontal gyrus, right hippocampus, right middle frontal gyrus, bilateral postcentral, and right superior temporal pole, while increased ALFF values in the left median cingulate and left calcarine. There was significant correlation between ALFF values in the altered regions and duration of disease in IBS. FC analysis revealed the increased connectivity between cingulate and frontal cortex in IBS. CONCLUSIONS: Our findings could provide both regional and brain connectivity spontaneous neuronal activity properties in IBS. SIGNIFICANCE: Our study may lead to a better understanding of intrinsic functional architecture of brain activity in IBS and highlight the potential for using the ALFF and FC metrics as a disease biomarker.
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