Jung Min Hwang1, Yun-Hee Kim2, Kyung Jae Yoon3, Kyeong Eun Uhm1, Won Hyuk Chang4. 1. Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 2. Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea. 3. Department of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 4. Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: wh.chang@samsung.com.
Abstract
OBJECTIVE: To investigate whether there is a relation between the plasticity induced by different intensities of facilitatory rTMS with different intensities and brain-derived neurotrophic factor (BDNF) genotype. METHODS: Forty healthy volunteers (14 men, mean age 27.3years) were enrolled. All participants received three high-frequency rTMS applications in random order over the non-dominant primary motor cortex with more than a 24-h washout period: 1st condition, rTMS with sub-threshold intensity; 2nd condition, rTMS with supra-threshold intensity; and 3rd condition, sham rTMS. Cortical excitability was assessed before and after rTMS using motor-evoked potentials (MEPs). Data were analyzed using the BDNF genotype. RESULTS: Twelve, 19, and 9 participants were classified into Val/Val, Val/Met, and Met/Met groups, respectively. In each group, there were significant increases in the amplitude of MEPs after 1st and 2nd conditions (P<0.05), but not after 3rd condition. In Val/Val group, the increase ratio of MEPs' amplitude after 2nd condition was significantly higher than 1st condition (P<0.05). However, no significant amplitude differences in Val/Met and Met/Met groups were observed after 1st and 2nd conditions. CONCLUSIONS: High-frequency rTMS induces the facilitation of cortical excitability regardless of BDNF genotype. BDNF genotype might influence on different responses of plasticity based on the rTMS intensity. SIGNIFICANCE: BDNF genotype is one of influence factors on the plasticity after the facilitatory rTMS.
OBJECTIVE: To investigate whether there is a relation between the plasticity induced by different intensities of facilitatory rTMS with different intensities and brain-derived neurotrophic factor (BDNF) genotype. METHODS: Forty healthy volunteers (14 men, mean age 27.3years) were enrolled. All participants received three high-frequency rTMS applications in random order over the non-dominant primary motor cortex with more than a 24-h washout period: 1st condition, rTMS with sub-threshold intensity; 2nd condition, rTMS with supra-threshold intensity; and 3rd condition, sham rTMS. Cortical excitability was assessed before and after rTMS using motor-evoked potentials (MEPs). Data were analyzed using the BDNF genotype. RESULTS: Twelve, 19, and 9 participants were classified into Val/Val, Val/Met, and Met/Met groups, respectively. In each group, there were significant increases in the amplitude of MEPs after 1st and 2nd conditions (P<0.05), but not after 3rd condition. In Val/Val group, the increase ratio of MEPs' amplitude after 2nd condition was significantly higher than 1st condition (P<0.05). However, no significant amplitude differences in Val/Met and Met/Met groups were observed after 1st and 2nd conditions. CONCLUSIONS: High-frequency rTMS induces the facilitation of cortical excitability regardless of BDNF genotype. BDNF genotype might influence on different responses of plasticity based on the rTMS intensity. SIGNIFICANCE: BDNF genotype is one of influence factors on the plasticity after the facilitatory rTMS.
Authors: L Marsili; A Suppa; F Di Stasio; D Belvisi; N Upadhyay; I Berardelli; M Pasquini; S Petrucci; M Ginevrino; G Fabbrini; F Cardona; G Defazio; A Berardelli Journal: Exp Brain Res Date: 2016-11-30 Impact factor: 1.972
Authors: Rohan Puri; Mark R Hinder; Hakuei Fujiyama; Rapson Gomez; Richard G Carson; Jeffery J Summers Journal: Front Aging Neurosci Date: 2015-06-05 Impact factor: 5.750
Authors: Denise Y Harvey; Laura DeLoretta; Priyanka P Shah-Basak; Rachel Wurzman; Daniela Sacchetti; Ahmed Ahmed; Abdou Thiam; Falk W Lohoff; Olufunsho Faseyitan; Roy H Hamilton Journal: Front Hum Neurosci Date: 2021-06-18 Impact factor: 3.169