| Literature DB >> 25453445 |
Hucheng Zhu1, Chunmei Chen, Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao, Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue, Yonghui Zhang.
Abstract
Hyperisampsins A-D (1-4), with tetracyclo[6.3.1.1(3,10).0(3,7)]tridecane skeletons and seven biogenetically related congeners (5-11), were isolated from Hypericum sampsonii. Their structures were elucidated by comprehensive spectroscopic techniques. The absolute configuration of 1 was established by ECD calculations, and those of 5 and 9 were confirmed by single X-ray crystallographic analyses. Hyperisampsins A and D showed potent anti-HIV activities with EC50 of 2.97 and 0.97 μM and selectivity index of 4.80 and 7.70, respectively.Entities:
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Year: 2014 PMID： 25453445 DOI： 10.1021/ol5030579
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005