Gabrio Bassotti1, Elisabetta Antonelli2, Vincenzo Villanacci3, Monia Baldoni1, Maria Pina Dore4. 1. Gastroenterology Section, Department of Medicine, University of Perugia, Perugia, Italy. 2. Gastroenterology Unit, Perugia General Hospital, Perugia, Italy. 3. Pathology Section, Department of Molecular and Translational Medicine, Spedali Civili and University of Brescia, Italy. 4. Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy ; Baylor College of Medicine, Houston, Texas, USA.
Abstract
BACKGROUND: Inflammatory conditions affecting the gut may cause motility disturbances, and ulcerative colitis - one of the main disorders among the inflammatory bowel diseases - may display abnormal colonic motility. AIM: To review the abnormalities of the large bowel in ulcerative colitis, by considering the motility, laboratory (in vitro) and pathological studies dealing with this topic. METHODS: A comprehensive online search of Medline and the Science Citation Index was carried out. RESULTS: Patients with ulcerative colitis frequently display colonic motor abnormalities, including lack of contractility, an increase of propulsive contractile waves, an excessive production of nitric oxide, vasoactive intestinal polypeptide nerves, interleukin 1 beta, neurotensin, tachykinins levels and the weaker action of substance P, likely related to a neuromuscular dysfunction due to the inflammatory process. CONCLUSIONS: A better understanding of the pathophysiological grounds of altered colonic motility in ulcerative colitis may lead to a more in-depth knowledge of the accompanying symptoms and to better and more targeted therapeutic approaches.
BACKGROUND: Inflammatory conditions affecting the gut may cause motility disturbances, and ulcerative colitis - one of the main disorders among the inflammatory bowel diseases - may display abnormal colonic motility. AIM: To review the abnormalities of the large bowel in ulcerative colitis, by considering the motility, laboratory (in vitro) and pathological studies dealing with this topic. METHODS: A comprehensive online search of Medline and the Science Citation Index was carried out. RESULTS:Patients with ulcerative colitis frequently display colonic motor abnormalities, including lack of contractility, an increase of propulsive contractile waves, an excessive production of nitric oxide, vasoactive intestinal polypeptide nerves, interleukin 1 beta, neurotensin, tachykinins levels and the weaker action of substance P, likely related to a neuromuscular dysfunction due to the inflammatory process. CONCLUSIONS: A better understanding of the pathophysiological grounds of altered colonic motility in ulcerative colitis may lead to a more in-depth knowledge of the accompanying symptoms and to better and more targeted therapeutic approaches.
Authors: W Pascale Ter Beek; Eveline S M Muller; Marlies van den Berg; Martin J Meijer; Izäk Biemond; Cornelis B H W Lamers Journal: Inflamm Bowel Dis Date: 2008-05 Impact factor: 5.325
Authors: Georg B T von Boyen; Nadine Schulte; Carolin Pflüger; Ulrike Spaniol; Christoph Hartmann; Martin Steinkamp Journal: BMC Gastroenterol Date: 2011-01-14 Impact factor: 3.067
Authors: Claire M Smyth; Nadim Akasheh; Sara Woods; Elaine Kay; Ross K Morgan; Margaret A Thornton; Anthony O'Grady; Robert Cummins; Orla Sheils; Peter Smyth; Gerald J Gleich; Frank M Murray; Richard W Costello Journal: PLoS One Date: 2013-05-22 Impact factor: 3.240
Authors: G Bassotti; E Antonelli; V Villanacci; R Nascimbeni; M P Dore; G M Pes; G Maconi Journal: Tech Coloproctol Date: 2020-02-15 Impact factor: 3.781