Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cardiac arrhythmias modelled by Cai-inactivated Ca2+ channels.

Literature DB >> 2545279

Cardiac arrhythmias modelled by Cai-inactivated Ca2+ channels.

Abstract

A model of cardiac cells incorporating the membrane potential and the intracellular calcium concentration as the two dynamical variables is developed. This model is applied to simple systems of cells to investigate its behavior as a function of the model parameters. Rational entrainment is observed in systems of two coupled pacemaker cells. The propagation of the membrane potential and intracellular calcium concentration through a sheet is simulated. Behavior suggestive of circus movement tachycardias is observed.

Entities: Chemical Disease

Mesh：

Substances：
Calcium Channels
Calcium

Year: 1989 PMID： 2545279 DOI： 10.1007/BF00204756

Source DB: PubMed Journal: Biol Cybern ISSN： 0340-1200 Impact factor: 2.086

Keyword Cloud
References

15 in total

Cardiac arrhythmias modelled by Cai-inactivated Ca2+ channels.

1. Reconstruction of the electrical activity of cardiac Purkinje fibres.

2. A COMPUTER MODEL OF ATRIAL FIBRILLATION.

3. A quantitative description of membrane current and its application to conduction and excitation in nerve.

Review 4. A model of cardiac electrical activity incorporating ionic pumps and concentration changes.

5. The slow inward current, isi, in the rabbit sino-atrial node investigated by voltage clamp and computer simulation.

6. A mathematical model of the effects of acetylcholine pulses on sinoatrial pacemaker activity.

7. Propagation through electrically coupled cells. Effects of regional changes in membrane properties.

8. Mutual entrainment of two pacemaker cells. A study with an electronic parallel conductance model.

9. Reconstruction of sino-atrial node pacemaker potential based on the voltage clamp experiments.

10. Computer simulation of arrhythmias in a network of coupled excitable elements.